{"doi":"10.46292/sci22-00006","title":"Identifying Body Awareness-Related Brain Network Changes After Cognitive Multisensory Rehabilitation for Neuropathic Pain Relief in Adults With Spinal Cord Injury: Protocol of a Phase I Randomized Controlled Trial","abstract":"Background: About 69% of the 299,000 Americans living with spinal cord injury (SCI) experience long-term debilitating neuropathic pain. New treatments are needed because current treatments do not provide enough pain relief. We have found that insular-opercular brain network alterations may contribute to neuropathic pain and that restoring this network could reduce neuropathic pain. Here, we outline a study protocol using a physical therapy approach, cognitive multisensory rehabilitation (CMR), which has been shown to restore OP1/OP4 connections in adults post stroke, to test our hypothesis that CMR can normalize pain perception through restoring OP1/OP4 connectivity in adults with SCI and relieve neuropathic pain. Objectives: To compare baseline brain function via resting-state and task-based functional magnetic resonance imaging in adults with SCI versus uninjured controls, and to identify changes in brain function and behavioral pain outcomes after CMR in adults with SCI. Methods: In this phase I randomized controlled trial, adults with SCI will be randomized into two groups: Group A will receive 6 weeks of CMR followed by 6 weeks of standard of care (no therapy) at home. Group B will start with 6 weeks of standard of care (no therapy) at home and then receive 6 weeks of CMR. Neuroimaging and behavioral measures are collected at baseline, after the first 6 weeks (A: post therapy, B: post waitlist), and after the second 6 weeks (A: post-therapy follow-up, B: post therapy), with follow-up of both groups up to 12 months. Conclusion: The successful outcome of our study will be a critical next step toward implementing CMR in clinical care to improve health in adults with SCI.","journal":"Topics in Spinal Cord Injury Rehabilitation","year":2022,"id":265529,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9559,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":430293,"name":"Sydney Carpentier","orcid":"0000-0003-2398-085X","position":1,"is_corresponding":false},{"id":924648,"name":"Wei Deng","orcid":"0000-0002-7933-389X","position":2,"is_corresponding":false},{"id":924649,"name":"Sara Bottale","orcid":"0009-0004-2160-2761","position":3,"is_corresponding":false},{"id":340188,"name":"Timothy Hendrickson","orcid":"0000-0001-6862-6526","position":4,"is_corresponding":false},{"id":363575,"name":"Lin Zhang","orcid":"0000-0002-0003-6084","position":5,"is_corresponding":false},{"id":924650,"name":"Robert Wudlick","orcid":"0000-0001-6021-1238","position":6,"is_corresponding":false},{"id":442021,"name":"Clas Linnman","orcid":"0000-0001-8449-894X","position":7,"is_corresponding":false},{"id":738752,"name":"Ricardo A. Battaglino","orcid":"0000-0002-0272-1763","position":8,"is_corresponding":false},{"id":533136,"name":"Leslie R. Morse","orcid":"0000-0002-7426-6341","position":9,"is_corresponding":false},{"id":384881,"name":"Ann Van de Winckel","orcid":"0000-0001-8400-3177","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T00:26:49.862989Z","pmid":"36457363","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}