{"doi":"10.4324/9780429200151-109","title":"Exploration of the Nanomedicine-Design Space with High-throughput Screening and Machine Learning*","abstract":"Only a tiny fraction of the nanomedicine-design space has been explored, owing to the structural complexity of nanomedicines and the lack of relevant high-throughput synthesis and analysis methods. Nanotechnology is beginning to play a major role in the development of new therapeutic modalities. Immunostimulatory SNAs consist of three modular components— the nanoparticle core, oligonucleotide shell and peptide antigen— each of which can be arranged in a variety of configurations. Varying the design parameters of SNAs induced a broad range of immune activation. Because of the dominant effects of conjugation chemistry, we analysed the remaining SNA properties separately for SNAs with cholesterol- and DOPE-conjugated oligonucleotides. Similar to well-known trends with linear oligonucleotides, the oligonucleotide backbone also influenced the immunostimulatory activity of the SNAs. Surprisingly, there was not a strong or consistent trend in how oligonucleotide density affected activity, with neither the highest nor lowest densities showing the best activity.","journal":"Spherical Nucleic Acids","year":2020,"id":117166,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":488517,"name":"Eric J. Berns","orcid":"0000-0002-2203-0847","position":1,"is_corresponding":false},{"id":528872,"name":"Albert Xue","orcid":"0000-0001-8561-9416","position":2,"is_corresponding":false},{"id":478839,"name":"Andrew Lee","orcid":"0000-0002-7665-1999","position":3,"is_corresponding":false},{"id":287700,"name":"Neda Bagheri","orcid":"0000-0003-0146-4627","position":4,"is_corresponding":false},{"id":268924,"name":"Milan Mrksich","orcid":"0000-0002-4964-796X","position":5,"is_corresponding":false},{"id":79412,"name":"Chad A. Mirkin","orcid":"0000-0002-6634-7627","position":6,"is_corresponding":false},{"id":547304,"name":"Gokay Yamanluirt","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:51.309289Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}