{"doi":"10.4274/tjps.galenos.2018.59389","title":"Synthesis and Anticancer and Antimicrobial Evaluation of Novel Ether-linked Derivatives of Ornidazole","abstract":"OBJECTIVES: were designed and synthesized. MATERIALS AND METHODS: in acetonitrile. RESULTS: on K562 leukemia and NIH/3T3 mouse embryonic fibroblast cells were measured. As a part of this study, the compliance of the compounds with the drug-likeness properties was evaluated. The physico-chemical parameters (log P, TPSA, nrotb, number of hydrogen bond donors and acceptors, logS) were calculated using the software OSIRIS. CONCLUSION: as compared to the standard drug, whereas antileukemic activities were rather limited. Furthermore, all the compounds were nontoxic and the selectivity index outcome indicated that the antileukemic and antimicrobial effects of the compounds were selective with good estimated oral bioavailability and drug-likeness scores.","journal":"Turkish Journal of Pharmaceutical Sciences","year":2020,"id":109927,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9174,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":523930,"name":"Necla Kulabaş","orcid":"0000-0003-2273-5094","position":1,"is_corresponding":false},{"id":523931,"name":"Özlem Bingöl Özakpınar","orcid":"0000-0003-0287-5639","position":2,"is_corresponding":false},{"id":523932,"name":"Sadık Kalaycı","orcid":"0000-0002-4449-5290","position":3,"is_corresponding":false},{"id":523933,"name":"Fikrettin Şahi̇n","orcid":"0000-0003-1503-5567","position":4,"is_corresponding":false},{"id":523934,"name":"İlkay Küçükgüzel","orcid":"0000-0002-7188-1859","position":5,"is_corresponding":false},{"id":523935,"name":"Ş. Güniz Küçükgüzel","orcid":"0000-0001-9405-8905","position":6,"is_corresponding":false},{"id":523929,"name":"Sevil Şenkardeş","orcid":"0000-0002-0523-459X","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-18T23:12:54.309019Z","pmid":"32454765","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}