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Measles virus was identified in 39.8% of cases, primarily among children. Other findings included <jats:italic>Plasmodium</jats:italic> spp. (12%), <jats:italic>Salmonella</jats:italic> spp. (13%), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; 8.7%). The virome capture sequencing platform for vertebrate viruses was used for 101 subjects, corroborating many routine test results and identifying additional cases of measles virus (1), SARS-CoV-2 (5), and numerous other agents. Notably, nearly all subjects showed evidence of herpesviruses (90%) and anelloviruses (98%). Hemorrhagic fever viruses were not observed. With the inclusion of VirCapSeq-VERT, identifiable pathogens were found in 79.6% of cases, leaving 20.4% without a clear etiology. The identification of more than one concurrent pathogen was common (41.5%). Integrating metagenomic sequencing with routine laboratory diagnostic testing enhances the detection of pathogens in acute febrile illnesses, highlighting its potential value in identifying infectious etiologies in resource-limited settings.</jats:p>","journal":"The American Journal of Tropical Medicine and Hygiene","year":2025,"id":634144,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":467260,"name":"Fousseyni Kané","orcid":"0000-0002-9967-7956","position":1,"is_corresponding":false},{"id":321454,"name":"Aaron Neal","orcid":"0000-0001-7674-0038","position":2,"is_corresponding":false},{"id":1644539,"name":"Issa Konate","orcid":null,"position":3,"is_corresponding":false},{"id":1644541,"name":"Bintou Coulibaly","orcid":null,"position":4,"is_corresponding":false},{"id":1644543,"name":"Djeneba K. 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