{"doi":"10.4269/ajtmh.23-0203","title":"Susceptibility of Anopheles gambiae to Natural Plasmodium falciparum Infection: A Comparison between the Well-Established Anopheles gambiae s.s Line and a Newly Established Ugandan Anopheles gambiae s.s. Line","abstract":"<jats:title>ABSTRACT.</jats:title>\n<jats:p>Much of our understanding of malaria transmission comes from mosquito feeding assays using <jats:italic>Anopheles</jats:italic> mosquitoes from colonies that are well adapted to membrane feeding. This raises the question whether results from colony mosquitoes lead to overestimates of outcomes in wild <jats:italic>Anopheles</jats:italic> mosquitoes. We successfully established an <jats:italic>Anopheles</jats:italic> colony using progeny of wild <jats:italic>Anopheles gambiae</jats:italic> s.s. mosquitoes (Busia mosquitoes) and directly compared their susceptibility to infection with <jats:italic>Plasmodium falciparum</jats:italic> with the widely used <jats:italic>An. gambiae</jats:italic> s.s. mosquitoes (Kisumu mosquitoes) using gametocyte-infected Ugandan donor blood. The proportion of infectious feeds did not differ between Busia (71.8%, 23/32) and Kisumu (68.8%, 22/32, <jats:italic>P</jats:italic> = 1.00) mosquitoes. When correcting for random effects of donor blood, we observed a 23% higher proportion of infected Busia mosquitoes than infected Kisumu mosquitoes (RR, 1.23; 95% CI, 1.10–1.38, <jats:italic>P &lt;</jats:italic> 0.001). This study suggests that feeding assays with Kisumu mosquitoes do not overestimate outcomes in wild <jats:italic>An. gambiae</jats:italic> s.s. mosquitoes, the mosquito species most relevant to malaria transmission in Uganda.</jats:p>","journal":"The American Journal of Tropical Medicine and Hygiene","year":2024,"id":14237,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":113422,"name":"Ismail Onyige","orcid":null,"position":1,"is_corresponding":false},{"id":113423,"name":"Joseph Okoth","orcid":null,"position":2,"is_corresponding":false},{"id":113424,"name":"Eric Musasizi","orcid":null,"position":3,"is_corresponding":false},{"id":113425,"name":"Ambrose Oruni","orcid":null,"position":4,"is_corresponding":false},{"id":113426,"name":"Jordache Ramjith","orcid":null,"position":5,"is_corresponding":false},{"id":113427,"name":"Emmanuel Arinaitwe","orcid":null,"position":6,"is_corresponding":false},{"id":113428,"name":"John C. 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Donnelly","orcid":null,"position":10,"is_corresponding":false},{"id":113432,"name":"Teun Bousema","orcid":null,"position":11,"is_corresponding":false},{"id":113433,"name":"Melissa Conrad","orcid":null,"position":12,"is_corresponding":false},{"id":113434,"name":"Sara Lynn Blanken","orcid":null,"position":13,"is_corresponding":false},{"id":113421,"name":"Daniel Ayo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38150729","pmcid":"PMC10859803","openalex_id":"https://openalex.org/W4390266636","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"U19 AI089674","title":null},{"funder_name":"FIC NIH HHS","grant_id":"K01 TW010868","title":null},{"funder_name":"National Institutes of Health","grant_id":"5U19AI089674-06","title":"Laboratory Core"},{"funder_name":"European Commission","grant_id":"864180","title":"Quantifying the spread of P. falciparum malaria"},{"funder_name":"National Institutes of Health","grant_id":"5D43TW009343-07","title":"University of California Global Health Institute Program for Fellows and Scholars"},{"funder_name":"Wellcome Trust","grant_id":"203511","title":"Assessing the impacts of insecticide resistance on vectorial competence of Anopheles gambiae from Uganda"}],"total_grants":6,"fwci":0.2776,"citation_percentile":0.65276029,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://www.ajtmh.org/downloadpdf/journals/tpmd/aop/article-10.4269-ajtmh.23-0203/article-10.4269-ajtmh.23-0203.pdf","host_type":"journal"},{"url":"https://www.ajtmh.org/downloadpdf/journals/tpmd/aop/article-10.4269-ajtmh.23-0203/article-10.4269-ajtmh.23-0203.pdf","host_type":"HYBRID"},{"url":"https://www.ajtmh.org/downloadpdf/journals/tpmd/aop/article-10.4269-ajtmh.23-0203/article-10.4269-ajtmh.23-0203.pdf","host_type":"publisher"},{"url":"https://www.ajtmh.org/view/journals/tpmd/110/2/article-p209.xml","host_type":"publisher"},{"url":"https://www.ajtmh.org/downloadpdf/journals/tpmd/110/2/article-p209.xml","host_type":"publisher"},{"url":"https://doi.org/10.4269/ajtmh.23-0203","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38150729","host_type":"repository"},{"url":"https://orcid.org/0000-0003-4863-075X>;","host_type":"repository"},{"url":"https://escholarship.org/uc/item/4j41q57x","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10859803","host_type":"repository"},{"url":"https://hdl.handle.net/2066/303464","host_type":"repository"},{"url":"https://escholarship.org/content/qt4j41q57x/qt4j41q57x.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10859803/pdf/ajtmh.23-0203.pdf","host_type":"repository"},{"url":"https://repository.ubn.ru.nl//bitstream/handle/2066/303464/303464.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10859803","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10859803?pdf=render","host_type":"Europe_PMC"},{"url":"https://dx.doi.org/10.60692/e5gr6-cjd28","host_type":""},{"url":"https://dx.doi.org/10.60692/sycz1-esa98","host_type":""},{"url":"http://dx.doi.org/10.4269/ajtmh.23-0203","host_type":""},{"url":"https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/303464","host_type":""},{"url":"https://doi.org/https://doi.org/10.4269/ajtmh.23-0203","host_type":""}],"fields_of_study":["Malaria Research and Control","Mosquito-borne diseases and control","Diverse Scientific Research Studies","Medicine","Environmental Science","Biology","0302 clinical medicine","03 medical and health sciences","Humans","Animals","Anopheles","Plasmodium falciparum","Uganda","Malaria, Falciparum","Malaria","Mosquito Vectors"],"mesh_terms":["Mosquito Vectors","Animals","Anopheles","Humans","Malaria","Plasmodium falciparum","Uganda","Malaria, Falciparum"],"keywords":["Anopheles gambiae","Plasmodium falciparum","Biology","Anopheles","Malaria","Virology","Immunology","Medical Microbiology - 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