{"doi":"10.4269/ajtmh.21-0953","title":"Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir","abstract":"Highly effective vector control can reduce malaria burden significantly, but individuals with parasitemia provide a potential reservoir for onward transmission. We performed an empirical, non-parametric simulation based on cohort data from Tororo District, Uganda-an area with historically high but recently reduced malaria transmission-to estimate the effects of mass drug administration (MDA) and test-and-treat on parasite prevalence. We estimate that a single round of MDA would have accelerated declines in parasite prevalence dramatically over 2 years (cumulative parasite prevalence ratio [PPR], 0.34). This decline was mostly during the first year of administration (PPR, 0.23) and waned by 23 months (PPR, 0.74). Test-and-treat using a highly sensitive diagnostic had nearly the same effect as MDA at 1 year (PPR, 0.27) and required many fewer treatments. The impact of test-and-treat using a standard diagnostic was modest (PPR, 0.58 at 1 year). Our analysis suggests that in areas experiencing a dramatic reduction in malaria prevalence, MDA or test-and-treat with a highly sensitive diagnostic may be an effective way of reducing or eliminating the infectious reservoir temporarily. However, for sustained benefits, repeated rounds of the intervention or additional interventions are required.","journal":"American Journal of Tropical Medicine and Hygiene","year":2022,"id":290473,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9448,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":298998,"name":"Emmanuel Arinaitwe","orcid":"0000-0002-9769-0348","position":1,"is_corresponding":false},{"id":299000,"name":"Jessica Briggs","orcid":"0000-0002-8078-3898","position":2,"is_corresponding":false},{"id":298999,"name":"John Rek","orcid":"0000-0003-4063-0763","position":3,"is_corresponding":false},{"id":242457,"name":"Philip J. Rosenthal","orcid":"0000-0002-7953-7622","position":4,"is_corresponding":false},{"id":242453,"name":"Moses R. Kamya","orcid":"0000-0001-9106-4234","position":5,"is_corresponding":false},{"id":621664,"name":"Peter Olwoch","orcid":"0000-0002-7396-3348","position":6,"is_corresponding":false},{"id":73231,"name":"David L. Smith","orcid":"0000-0003-4367-3849","position":7,"is_corresponding":false},{"id":107136,"name":"Isabel Rodríguez-Barraquer","orcid":"0000-0001-6784-1021","position":8,"is_corresponding":false},{"id":242454,"name":"Grant Dorsey","orcid":"0000-0003-0740-0317","position":9,"is_corresponding":false},{"id":299001,"name":"Bryan Greenhouse","orcid":"0000-0003-0287-9111","position":10,"is_corresponding":false},{"id":260122,"name":"Joaniter I. Nankabirwa","orcid":"0000-0001-7818-3845","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T00:30:30.639224Z","pmid":"36191870","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}