{"doi":"10.4269/ajtmh.20-0749","title":"Determinants of Malaria Protective Immunity in Mice Immunized with Live Sporozoites during Trimethoprim–Sulfamethoxazole Prophylaxis","abstract":"HIV and malaria geographically overlap. Trimethoprim-sulfamethoxazole (TMP-SMX) is a drug widely used in HIV-exposed uninfected and infected children in malaria-endemic areas, and is known to have antimalarial effects. Further study in terms of antimalarial impact and effect on development of malaria-specific immunity is therefore essential. Using rodent malaria models, we previously showed that repeated Plasmodium exposure during TMP-SMX administration, or chemoprophylaxis vaccination (CVac), induces CD8 T-cell-dependent preerythrocytic immunity. However, humoral immune responses have been shown to be important in models of preerythrocytic immunity. Herein, we demonstrate that antibody-mediated responses contribute to protective immunity induced by CVac immune sera using TMP-SMX in models of homologous, but not heterologous, parasite species. Clinical studies must account for potential anti-Plasmodium antibody induced during TMP-SMX prophylaxis.","journal":"American Journal of Tropical Medicine and Hygiene","year":2020,"id":132047,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9527,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":379323,"name":"Tejram Sahu","orcid":"0000-0002-0912-7660","position":1,"is_corresponding":false},{"id":414015,"name":"Jillian Neal","orcid":"0009-0007-8840-0664","position":2,"is_corresponding":false},{"id":513819,"name":"Solomon Conteh","orcid":"0000-0002-4256-175X","position":3,"is_corresponding":false},{"id":587497,"name":"Tatiana Voza","orcid":null,"position":4,"is_corresponding":false},{"id":444710,"name":"William Borkowsky","orcid":null,"position":5,"is_corresponding":false},{"id":586990,"name":"Jean Langhorne","orcid":"0000-0002-2257-9733","position":6,"is_corresponding":false},{"id":236042,"name":"Patrick E. Duffy","orcid":"0000-0002-4483-5005","position":7,"is_corresponding":false},{"id":376641,"name":"Charlotte V. Hobbs","orcid":"0000-0003-4829-0791","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:16:07.542484Z","pmid":"33350377","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}