{"doi":"10.4269/ajtmh.1991.44.42","title":"A Spleen is not Necessary to Resolve Infections with Plasmodium yoelii","abstract":null,"journal":"The American Journal of Tropical Medicine and Hygiene","year":1991,"id":678387,"datarank":0.4636563680037475,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.0,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":974591,"name":"A. James Cooley","orcid":"0000-0002-9474-9922","position":1,"is_corresponding":false},{"id":1772494,"name":"Donald L. Wassom","orcid":null,"position":2,"is_corresponding":false},{"id":1772490,"name":"Peter C. Sayles","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Spleen is not Necessary to Resolve Infections with Plasmodium yoelii","abstract":"The role of the spleen in resistance to infections with nonlethal Plasmodium yoelii 17x is dependent upon the genotype of the host. Thus, DBA/2 (D2) mice infected with P. yoelii 17x were not adversely affected by removal of the spleen, while splenectomized C57BL/6 (B6) or Balb/c mice failed to resolve their infections and eventually died. The levels of parasitemia were lower in splenectomized mice compared to intact controls; however, splenectomized mice became as anemic as did spleen-intact controls. Splenectomy resulted in the appearance of large aggregates of mononuclear cells in the livers of infected mice and also altered the liver/body weight ratios. These results indicate that D2 mice have a spleen-independent mechanism of clearing parasites which is lacking in B6 and Balb/c mice.","is_dataset_classified":null,"base_score":3.091042453358316,"endowment":3.091042453358316,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1996740","pmcid":null,"openalex_id":"https://openalex.org/W2416843877","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"AI26904","title":null}],"total_grants":1,"fwci":1.5634,"citation_percentile":0.85317907,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2021,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.ajtmh.org/view/journals/tpmd/44/1/article-p42.xml","host_type":"publisher"},{"url":"https://www.ajtmh.org/downloadpdf/journals/tpmd/44/1/article-p42.xml","host_type":"publisher"},{"url":"https://doi.org/10.4269/ajtmh.1991.44.42","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1996740","host_type":"repository"}],"fields_of_study":["Malaria Research and Control","Vector-borne infectious diseases","Healthcare and Venom Research"],"mesh_terms":["Animals","Female","Immunity, Innate","Liver","Malaria","Mice, Inbred BALB C","Mice, Inbred C57BL","Mice, Inbred DBA","Organ Size","Plasmodium yoelii","Spleen","Splenectomy","Mice"],"keywords":["Plasmodium yoelii","Spleen","Parasitemia","Splenectomy","Biology","Immunology","Malaria","Virology","Plasmodium falciparum"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T05:22:06.641936Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}