{"doi":"10.4244/eij-d-23-00487","title":"Intravascular laser lithotripsy for calcium fracture in human coronary arteries","abstract":"BACKGROUND: Electrical intravascular lithotripsy (E-IVL) uses shock waves to fracture calcified plaque. AIMS: We aimed to demonstrate the ability of laser IVL (L-IVL) to fracture calcified plaques in ex vivo human coronary arteries and to identify and evaluate the mechanisms for increased vessel compliance. METHODS: Shock waves were generated by a Ho:YAG (Holmium: yttrium-aluminium-garnet) laser (2 J, 5 Hz) and recorded by a high-speed camera and pressure sensor. Tests were conducted on phantoms and 19 fresh human coronary arteries. Before and after L-IVL, arterial compliance and optical coherence tomography (OCT) pullbacks were recorded, followed by histology. Additionally, microcomputed tomography (micro-CT) and scanning electron microscopy (SEM) were performed. Finite element models (FEM) were utilised to examine the mechanism of L-IVL. RESULTS: (p<0.01). Arterial compliance increased by 2.3±0.6 atm/ml (p<0.05). FEM simulations suggest that debonding and intimal tears are additional mechanisms for increased arterial compliance. CONCLUSIONS: L-IVL has the capability to increase calcified coronary artery compliance by multiple mechanisms.","journal":"EuroIntervention","year":2023,"id":381326,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9691,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":559037,"name":"Nitesh Katta","orcid":"0000-0001-8097-5489","position":1,"is_corresponding":false},{"id":1125668,"name":"Drew Nolen","orcid":null,"position":2,"is_corresponding":false},{"id":711043,"name":"Scott Jenney","orcid":null,"position":3,"is_corresponding":false},{"id":340658,"name":"Deborah Vela","orcid":null,"position":4,"is_corresponding":false},{"id":338999,"name":"L. Maximilian Buja","orcid":"0000-0001-8386-7029","position":5,"is_corresponding":false},{"id":972112,"name":"Mehmet Çilingiroğlu","orcid":"0000-0003-3795-8645","position":6,"is_corresponding":false},{"id":727984,"name":"Yasamin Seddighi","orcid":null,"position":7,"is_corresponding":false},{"id":727359,"name":"Hai‐Chao Han","orcid":"0000-0002-3077-5814","position":8,"is_corresponding":false},{"id":559852,"name":"Thomas E. Milner","orcid":null,"position":9,"is_corresponding":false},{"id":349229,"name":"Marc D. Feldman","orcid":null,"position":10,"is_corresponding":false},{"id":267868,"name":"Aleksandra Gruslova","orcid":"0000-0003-3358-7015","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T01:17:08.831117Z","pmid":"38060282","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}