{"doi":"10.4239/wjd.v15.i10.2123","title":"Effect of cuproptosis on acute kidney injury after cardiopulmonary bypass in diabetic patients","abstract":"BACKGROUND: Cardiopulmonary bypass (CPB) is a common procedure in cardiac surgery. CPB is a high-risk factor for acute kidney injury (AKI), and diabetes is also such a factor. Diabetes can lead to copper overload. It is currently unclear whether AKI after CPB in diabetic patients is related to copper overload. AIM: To explore whether the occurrence of CPB-AKI in diabetic patients is associated with cuproptosis. METHODS: Blood and urine were collected from clinical diabetic and non-diabetic patients before and after CPB. Levels of copper ion, lactate, glucose, heat shock protein-70 (HSP-70), and dihydrolipoamide dehydrogenase (DLAT) were determined. A diabetic rat model was established and CPB was performed. The rats were assessed for the development of CPB-AKI, and for the association of AKI with cuproptosis by detecting copper levels, iron-sulfur cluster proteins and observation of mitochondrial structure by electron microscopy. RESULTS: CPB resulted in elevations of copper, lactate, HSP-70 and DLAT in blood and urine in both diabetic and non-diabetic patients. CPB was associated with pathologic and mitochondrial damage in the kidneys of diabetic rats. Cuproptosis-related proteins also appeared to be significantly reduced. CONCLUSION: CPB-AKI is associated with cuproptosis. Diabetes mellitus is an important factor aggravating CPB-AKI and cuproptosis.","journal":"World Journal of Diabetes","year":2024,"id":443328,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9705,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1257471,"name":"Yinan Wang","orcid":"0009-0009-2134-712X","position":1,"is_corresponding":false},{"id":1257927,"name":"Chuan-Bao Lv","orcid":null,"position":2,"is_corresponding":false},{"id":1257928,"name":"Zhong-Zhi Qiu","orcid":null,"position":3,"is_corresponding":false},{"id":253949,"name":"Lingxin Zhu","orcid":"0000-0002-6762-7882","position":4,"is_corresponding":false},{"id":1257472,"name":"Jinghui Shi","orcid":"0000-0002-1653-4221","position":5,"is_corresponding":false},{"id":1257929,"name":"Si-Ri-Gu-Leng Sana","orcid":null,"position":6,"is_corresponding":false},{"id":1257926,"name":"Xijin Deng","orcid":null,"position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T02:01:24.471942Z","pmid":"39493567","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}