{"doi":"10.4236/ojs.2021.115046","title":"A Flexible Joint Longitudinal-Survival Model for Analyzing Longitudinally Sampled Biomarkers","abstract":"We propose a flexible joint longitudinal-survival framework to examine the association between longitudinally collected biomarkers and a time-to-event endpoint. More specifically, we use our method for analyzing the survival outcome of end-stage renal disease patients with time-varying serum albumin measurements. Our proposed method is robust to common parametric assumptions in that it avoids explicit specification of the distribution of longitudinal responses and allows for a subject-specific baseline hazard in the survival component. Fully joint estimation is performed to account for uncertainty in the estimated longitudinal biomarkers that are included in the survival model.","journal":"Open Journal of Statistics","year":2021,"id":227098,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":831503,"name":"Tracy Holsclaw","orcid":null,"position":1,"is_corresponding":false},{"id":466113,"name":"Babak Shahbaba","orcid":"0000-0002-8102-1609","position":2,"is_corresponding":false},{"id":390091,"name":"Daniel L. Gillen","orcid":"0000-0003-0200-1771","position":3,"is_corresponding":false},{"id":831502,"name":"Sepehr Akhavan Masouleh","orcid":null,"position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:54:42.179886Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}