{"doi":"10.4161/nucl.28167","title":"Specifying peripheral heterochromatin during nuclear lamina reassembly","abstract":null,"journal":"Nucleus","year":2014,"id":591266,"datarank":1.3663612027134762,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.8330589934900641,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.8330589934900641,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":29,"citers_with_citation_signal":28,"citers_with_endowment":28,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1512776,"name":"Richard A Katz","orcid":null,"position":1,"is_corresponding":false},{"id":393406,"name":"Andrey Poleshko","orcid":"0000-0002-6656-2941","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Specifying peripheral heterochromatin during nuclear lamina reassembly","abstract":"A conserved organizational feature of eukaryotic nuclei is the peripheral heterochromatin compartment, which provides a protected area for epigenetically silent genes and gene-poor DNA. In metazoan cells this compartment is associated with the nuclear lamina, the protein meshwork at the inner edge of the nucleus. Heterochromatin-nuclear lamina interactions promote epigenetic gene silencing, which may drive many normal and diseased biological processes. We recently obtained evidence that a previously unstudied human protein, PRR14, participates in the tethering of heterochromatin to the inner nuclear periphery. PRR14 associates with the nuclear lamina and attaches to heterochromatin through its binding partner, heterochromatin protein 1 (HP1). After disassembly early in mitosis, PRR14 reassembles in two steps, first binding to anaphase chromosomes through HP1, followed by association with the nuclear lamina in telophase. PRR14 may thereby play a role in specifying HP1-bound heterochromatin for reattachment to the nuclear lamina at mitotic exit. Here we review the relevant literature, summarize our initial work, and provide additional comments and findings.","is_dataset_classified":null,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24637393","pmcid":"PMC4028353","openalex_id":"https://openalex.org/W2006976460","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"R01 CA071515","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK082498","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA006927","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01DK082498-02","title":"Discovery of Epigenetic Marks in Human Cells by High Throughput siRNA Screening"},{"funder_name":"National Institutes of Health","grant_id":"1R01CA071515-01","title":"INTEGRATION OF RETROVIRAL DNA--ACCESSING HOST TARGET DNA"}],"total_grants":5,"fwci":1.2996,"citation_percentile":0.78688464,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":5},{"year":2018,"count":1},{"year":2019,"count":7},{"year":2020,"count":4},{"year":2021,"count":4},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":4}],"oa_status":"gold","license":"CC BY NC","oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.4161/nucl.28167?needAccess=true","host_type":"journal"},{"url":"https://www.tandfonline.com/doi/pdf/10.4161/nucl.28167?needAccess=true","host_type":"publisher"},{"url":"http://www.tandfonline.com/doi/pdf/10.4161/nucl.28167","host_type":"publisher"},{"url":"https://doi.org/10.4161/nucl.28167","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24637393","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4028353","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4028353","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4028353?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.4161/nucl.28167","host_type":""},{"url":"https://dx.doi.org/10.4161/nucl.28167","host_type":""}],"fields_of_study":["Nuclear Structure and Function","Genomics and Chromatin Dynamics","RNA Research and Splicing","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Chromobox Protein Homolog 5","Cell Nucleus","Chromosomal Proteins, Non-Histone","DNA-Binding Proteins","Heterochromatin","Humans","Mitosis","Microscopy, Confocal","Gene Silencing","Nuclear Lamina","Epigenesis, Genetic"],"keywords":["Heterochromatin","Nuclear lamina","Heterochromatin protein 1","Biology","Constitutive heterochromatin","Telophase","Cell biology","Mitosis","Euchromatin","Genetics","Nuclear protein","Chromatin","Chromosome","Gene","Anaphase","Transcription factor","Nuclear envelope","Proline-rich 14","Cell Nucleus","Microscopy, Confocal","Chromosomal Proteins, Non-Histone","Extra View","Epigenesis, Genetic","DNA-Binding Proteins","Chromobox Protein Homolog 5","Humans","Gene Silencing"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. 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