{"doi":"10.4161/cib.20364","title":"Neuron-specific regulation on F-actin cytoskeletons","abstract":null,"journal":"Communicative & Integrative Biology","year":2012,"id":654164,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1707233,"name":"Yi-Ping Hsueh","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Neuron-specific regulation on F-actin cytoskeletons","abstract":"Dendritic spines are neuron-specific actin-rich subcellular structures and are the location of excitatory synapses. Neurotransmitters released from presynaptic terminals activate the signals modifying the F-actin dynamics and stability and thus control dendritic spine morphology. Many ubiquitously expressed actin-associated proteins, including cortactin, have been shown to regulate dendritic spine morphology and density. Since dendritic spines are neuron-specific structures, neuron-specific proteins are expected to control F-actin cytoskeletons and dendritic spinogenesis. Recently, we demonstrated that cortactin-binding protein 2 (CTTNBP2), a neuron-specific protein, regulates the mobility and distribution of cortactin and controls the density of dendritic spines. This is the first example of a neuron-specific protein that controls the mobility of an F-actin associated protein and influences the dendritic spines. It provides a platform to explore the specific pathway triggering dendritic spinogenesis.","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23060955","pmcid":"PMC3460836","openalex_id":"https://openalex.org/W2045158358","authors":[],"funders":[],"total_grants":0,"fwci":0.2582,"citation_percentile":0.52537894,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2016,"count":2},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":3},{"year":2023,"count":2},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.4161/cib.20364?needAccess=true","host_type":"journal"},{"url":"https://www.tandfonline.com/doi/pdf/10.4161/cib.20364?needAccess=true","host_type":"publisher"},{"url":"http://www.tandfonline.com/doi/pdf/10.4161/cib.20364","host_type":"publisher"},{"url":"https://doi.org/10.4161/cib.20364","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23060955","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3460836","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3460836","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3460836?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cellular Mechanics and Interactions","Force Microscopy Techniques and Applications","Advanced Fluorescence Microscopy Techniques"],"mesh_terms":[],"keywords":["Dendritic spine","Cortactin","Neuron","Dendritic filopodia","Cell biology","Actin","Actin remodeling of neurons","Biology","Chemistry","Cytoskeleton","Actin cytoskeleton","Neuroscience","Hippocampal formation","Cell","Biochemistry","Cttnbp2","Cttnbp2-nl","Dendritic Spine Formation","F-actin-associated Protein"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T04:17:25.433286Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}