{"doi":"10.4161/cc.25692","title":"Proteasome-dependent degradation of replisome components regulates faithful DNA replication","abstract":null,"journal":"Cell Cycle","year":2013,"id":635322,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":717463,"name":"Chiaki Noguchi","orcid":null,"position":1,"is_corresponding":false},{"id":500949,"name":"Eishi Noguchi","orcid":"0000-0001-5470-5127","position":2,"is_corresponding":false},{"id":1648284,"name":"Laura C Roseaulin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Proteasome-dependent degradation of replisome components regulates faithful DNA replication","abstract":"The replication machinery, or the replisome, collides with a variety of obstacles during the normal process of DNA replication. In addition to damaged template DNA, numerous chromosome regions are considered to be difficult to replicate owing to the presence of DNA secondary structures and DNA-binding proteins. Under these conditions, the replication fork stalls, generating replication stress. Stalled forks are prone to collapse, posing serious threats to genomic integrity. It is generally thought that the replication checkpoint functions to stabilize the replisome and replication fork structure upon replication stress. This is important in order to allow DNA replication to resume once the problem is solved. However, our recent studies demonstrated that some replisome components undergo proteasome-dependent degradation during DNA replication in the fission yeast Schizosaccharomyces pombe. Our investigation has revealed the involvement of the SCF(Pof3) (Skp1-Cullin/Cdc53-F-box) ubiquitin ligase in replisome regulation. We also demonstrated that forced accumulation of the replisome components leads to abnormal DNA replication upon replication stress. Here we review these findings and present additional data indicating the importance of replisome degradation for DNA replication. Our studies suggest that cells activate an alternative pathway to degrade replisome components in order to preserve genomic integrity.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23907116","pmcid":"PMC3865046","openalex_id":"https://openalex.org/W2034501681","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM077604","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01GM077604-05","title":"Studies of the Swi1-Swi3 Replication Fork Protection Complex"}],"total_grants":2,"fwci":0.5505,"citation_percentile":0.65886217,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":3},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":1}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.25692?needAccess=true","host_type":"journal"},{"url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.25692?needAccess=true","host_type":"publisher"},{"url":"http://www.tandfonline.com/doi/pdf/10.4161/cc.25692","host_type":"publisher"},{"url":"https://doi.org/10.4161/cc.25692","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23907116","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3865046","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3865046","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3865046?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.4161/cc.25692","host_type":""},{"url":"https://dx.doi.org/10.4161/cc.25692","host_type":""}],"fields_of_study":["DNA Repair Mechanisms","Microtubule and mitosis dynamics","Mitochondrial Function and Pathology","0301 basic medicine","03 medical and health sciences","DNA Helicases","DNA Replication","Models, Genetic","Phosphatidylinositol 3-Kinases","Proteasome Endopeptidase Complex","SKP Cullin F-Box Protein Ligases","Schizosaccharomyces"],"mesh_terms":["DNA Replication","DNA Helicases","Models, Genetic","Schizosaccharomyces","Phosphatidylinositol 3-Kinases","SKP Cullin F-Box Protein Ligases","Proteasome Endopeptidase Complex"],"keywords":["Replisome","Biology","Pre-replication complex","Control of chromosome duplication","DNA replication","Eukaryotic DNA replication","Origin recognition complex","Cell biology","Replication factor C","Minichromosome maintenance","Genetics","DNA","Proteasome","Protein degradation","Ubiquitin Ligase","F-box","Fpc","Replication Fork Protection Complex","Extra Views","Phosphatidylinositol 3-Kinases","Proteasome Endopeptidase Complex","SKP Cullin F-Box Protein Ligases","Models, Genetic","Schizosaccharomyces","DNA Helicases"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:56:00.537685Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}