{"doi":"10.4161/15384101.2014.994988","title":"Human Nek7-interactor RGS2 is required for mitotic spindle organization","abstract":null,"journal":"Cell Cycle","year":2015,"id":620589,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":355299,"name":"Heidi Hehnly","orcid":"0000-0001-6660-5254","position":1,"is_corresponding":false},{"id":700069,"name":"Arina Marina Perez","orcid":null,"position":2,"is_corresponding":false},{"id":1602085,"name":"Gabriela Vaz Meirelles","orcid":null,"position":3,"is_corresponding":false},{"id":1602086,"name":"Juliana Helena Costa Smetana","orcid":null,"position":4,"is_corresponding":false},{"id":1602088,"name":"Stephen Doxsey","orcid":null,"position":5,"is_corresponding":false},{"id":699467,"name":"Jörg Kobarg","orcid":"0000-0002-9419-0145","position":6,"is_corresponding":false},{"id":1602084,"name":"Edmarcia Elisa de Souza","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Human Nek7-interactor RGS2 is required for mitotic spindle organization","abstract":"The mitotic spindle apparatus is composed of microtubule (MT) networks attached to kinetochores organized from 2 centrosomes (a.k.a. spindle poles). In addition to this central spindle apparatus, astral MTs assemble at the mitotic spindle pole and attach to the cell cortex to ensure appropriate spindle orientation. We propose that cell cycle-related kinase, Nek7, and its novel interacting protein RGS2, are involved in mitosis regulation and spindle formation. We found that RGS2 localizes to the mitotic spindle in a Nek7-dependent manner, and along with Nek7 contributes to spindle morphology and mitotic spindle pole integrity. RGS2-depletion leads to a mitotic-delay and severe defects in the chromosomes alignment and congression. Importantly, RGS2 or Nek7 depletion or even overexpression of wild-type or kinase-dead Nek7, reduced γ-tubulin from the mitotic spindle poles. In addition to causing a mitotic delay, RGS2 depletion induced mitotic spindle misorientation coinciding with astral MT-reduction. We propose that these phenotypes directly contribute to a failure in mitotic spindle alignment to the substratum. In conclusion, we suggest a molecular mechanism whereupon Nek7 and RGS2 may act cooperatively to ensure proper mitotic spindle organization.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25664600","pmcid":"PMC4614950","openalex_id":"https://openalex.org/W2046027569","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"#NIH K99-GM107355","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"NIH RO1 GM051994-14","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"K99 GM107355","title":null},{"funder_name":"National Institutes of Health","grant_id":"1K99GM107355-01","title":"Mother Centriole Appendages Regulate the AMIS Compartment and Cilogenesis."}],"total_grants":4,"fwci":1.0188,"citation_percentile":0.73416241,"influential_citations":0,"citation_trend":[{"year":2016,"count":3},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":7},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.994988?needAccess=true","host_type":"journal"},{"url":"https://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.994988?needAccess=true","host_type":"publisher"},{"url":"https://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.994988","host_type":"publisher"},{"url":"https://doi.org/10.4161/15384101.2014.994988","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25664600","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4614950","host_type":"repository"},{"url":"https://dx.doi.org/10.4161/15384101.2014.994988","host_type":""}],"fields_of_study":["Microtubule and mitosis dynamics","Genomics and Chromatin Dynamics","Plant nutrient uptake and metabolism","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["NIMA-Related Kinases","Cloning, Molecular","Humans","Image Processing, Computer-Assisted","Microscopy, Fluorescence","Mitosis","Spindle Apparatus","Phosphorylation","Plasmids","Tubulin","Protein Serine-Threonine Kinases","RGS Proteins","Two-Hybrid System Techniques","Time-Lapse Imaging"],"keywords":["Spindle apparatus","Cell biology","Spindle pole body","Mitosis","Mitotic exit","Biology","Spindle checkpoint","Aurora B kinase","Multipolar spindles","Kinetochore","Astral microtubules","Centrosome","Cell division","Genetics","Cell cycle","Cell","Chromosome","Mitotic Spindle","Gap, Gtpase-activating Protein","Rgs2","Mitotic Spindle Orientation","Ppi, Protein-protein Interaction","Mt, Microtubule","Wb, Western Blotting","Nek7","Crest, Calcium-responsive Transactivator","Eb1, End-binding Protein 1","Nek, Nima-related Kinase","Pcm, Centrosomal Pericentriolar Material","Pd, Pull-down","Rgs, Regulators Of G Protein Signaling","Shrna, Short-interfering Rna","Protein Serine-Threonine Kinases","Time-Lapse Imaging","Microscopy, Fluorescence","Tubulin","Two-Hybrid System Techniques","Image Processing, Computer-Assisted","Humans","NIMA-Related Kinases","Cloning, Molecular","Phosphorylation","RGS Proteins","Plasmids"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T11:31:43.705026Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}