{"doi":"10.4155/fmc.15.78","title":"Beyond Cyclosporine A: Conformation-Dependent Passive Membrane Permeabilities of Cyclic Peptide Natural Products","abstract":null,"journal":"Future Medicinal Chemistry","year":2015,"id":654297,"datarank":0.7781078708761133,"base_score":5.187385805840755,"endowment":5.187385805840755,"self_citation_contribution":0.7781078708761133,"citation_network_contribution":0.0,"self_endowment_contribution":0.7781078708761133,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":178,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1707573,"name":"Katrina W Lexa","orcid":null,"position":1,"is_corresponding":false},{"id":1707574,"name":"Andrew T Bockus","orcid":null,"position":2,"is_corresponding":false},{"id":984234,"name":"Valerie Chen","orcid":"0009-0007-2783-0265","position":3,"is_corresponding":false},{"id":366419,"name":"Phillip Crews","orcid":"0000-0002-9061-9549","position":4,"is_corresponding":false},{"id":1642213,"name":"Matthew P Jacobson","orcid":null,"position":5,"is_corresponding":false},{"id":1707575,"name":"R Scott Lokey","orcid":null,"position":6,"is_corresponding":false},{"id":1707572,"name":"Christopher L Ahlbach","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Beyond Cyclosporine A: Conformation-Dependent Passive Membrane Permeabilities of Cyclic Peptide Natural Products","abstract":"Many cyclic peptide natural products are larger and structurally more complex than conventional small molecule drugs. Although some molecules in this class are known to possess favorable pharmacokinetic properties, there have been few reports on the membrane permeabilities of cyclic peptide natural products. Here, we present the passive membrane permeabilities of 39 cyclic peptide natural products, and interpret the results using a computational permeability prediction algorithm based on their known or calculated 3D conformations. We found that the permeabilities of these compounds, measured in a parallel artificial membrane permeability assay, spanned a wide range and demonstrated the important influence of conformation on membrane permeability. These results will aid in the development of these compounds as a viable drug paradigm.","is_dataset_classified":null,"base_score":5.187385805840755,"endowment":5.187385805840755,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26067057","pmcid":"PMC5186412","openalex_id":"https://openalex.org/W2186110136","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"GM100619","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"F32 GM100619","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA047135","title":null}],"total_grants":3,"fwci":4.962,"citation_percentile":0.961625,"influential_citations":0,"citation_trend":[{"year":2015,"count":2},{"year":2016,"count":8},{"year":2017,"count":15},{"year":2018,"count":11},{"year":2019,"count":14},{"year":2020,"count":19},{"year":2021,"count":18},{"year":2022,"count":32},{"year":2023,"count":15},{"year":2024,"count":20},{"year":2025,"count":17},{"year":2026,"count":7}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5186412","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5186412","host_type":"repository"},{"url":"https://www.tandfonline.com/doi/pdf/10.4155/fmc.15.78","host_type":"publisher"},{"url":"https://doi.org/10.4155/fmc.15.78","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26067057","host_type":"repository"},{"url":"https://escholarship.org/uc/item/8bm7g6d5","host_type":""}],"fields_of_study":["Chemical Synthesis and Analysis","Antimicrobial Peptides and Activities","Biochemical and Structural Characterization","Biological Products","Cell Membrane Permeability","Cyclosporine","Humans","Membranes, Artificial","Peptides, Cyclic"],"mesh_terms":["Biological Products","Cell Membrane Permeability","Humans","Membranes, Artificial","Peptides, Cyclic","Cyclosporine"],"keywords":["Cyclic peptide","Membrane","Peptide","Membrane permeability","Chemistry","Permeability (electromagnetism)","Molecule","Cell permeability","Small molecule","Biophysics","Molecular dynamics","Combinatorial chemistry","Biochemistry","Computational chemistry","Organic chemistry","Biology","Permeability","cyclosporine","Pampa"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T05:39:25.413515Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}