{"doi":"10.4155/fmc-2019-0063","title":"<i>Bis</i> -(Imidazole/Benzimidazole)-Pyridine Derivatives: Synthesis, Structure and Antimycobacterial Activity","abstract":"Aim: Over the last decades, few significant achievements have been made in tuberculosis (TB) therapy. As a result, there is an urgent need for new anti-TB drugs. Results: Two new classes of bis-(imidazole/benzimidazole)-pyridine derivatives were designed, synthesized and evaluated for their antimycobacterial activity. Conclusion: The synthesis is efficient and straightforward, involving only two successive N-alkylations. The anti-TB assay reveal that our compounds have an excellent anti-TB activity against both replicating and nonreplicating Mtb, are not cytotoxic, exhibited a very good intracellular activity and are active against drug-resistant Mtb strains, some compounds have a bactericidal mechanism. The absorption, distribution, metabolism, excretion and toxicity studies performed for one compound are promising, indicating that it is a good candidate for a future drug.","journal":"Future Medicinal Chemistry","year":2020,"id":61480,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9598,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":325096,"name":"Dumitrela Diaconu","orcid":"0000-0001-9157-3995","position":1,"is_corresponding":false},{"id":325097,"name":"Gheorghiță Zbancioc","orcid":"0000-0001-9871-4156","position":2,"is_corresponding":false},{"id":325098,"name":"Costel Moldoveanu","orcid":"0000-0002-9972-5372","position":3,"is_corresponding":false},{"id":325099,"name":"Violeta Mangalagiu","orcid":"0000-0002-9768-8686","position":4,"is_corresponding":false},{"id":325100,"name":"Dorina Amăriucăi-Mantu","orcid":"0000-0001-8744-7742","position":5,"is_corresponding":false},{"id":325101,"name":"Aculina Arîcu","orcid":"0000-0001-7201-2519","position":6,"is_corresponding":false},{"id":325102,"name":"Ionel I. Mangalagiu","orcid":"0000-0002-4632-5076","position":7,"is_corresponding":false},{"id":325095,"name":"Vasilichia Antoci","orcid":"0000-0003-1013-1293","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-18T21:09:47.114172Z","pmid":"31916456","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}