{"doi":"10.4155/fdd-2019-0032","title":"How Polypharmacologic is Each Chemogenomics Library?","abstract":"AIM: High-throughput phenotypic screens have emerged as a promising avenue for small-molecule drug discovery. The challenge faced in high-throughput phenotypic screens is target deconvolution once a small molecule hit is identified. Chemogenomics libraries have emerged as an important tool for meeting this challenge. Here, we investigate their target-specificity by deriving a 'polypharmacology index' for broad chemogenomics screening libraries. METHODS: All known targets of all the compounds in each library were plotted as a histogram and fitted to a Boltzmann distribution, whose linearized slope is indicative of the overall polypharmacology of the library. RESULTS & CONCLUSION: Comparison of libraries clearly distinguished the most target-specific library, which might be assumed to be more useful for target deconvolution in a phenotypic screen.","journal":"Future Drug Discovery","year":2020,"id":107086,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9328,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":515876,"name":"Eehjoe Kwon","orcid":null,"position":1,"is_corresponding":false},{"id":515282,"name":"Lauren M. Young","orcid":"0000-0002-2795-3536","position":2,"is_corresponding":false},{"id":515877,"name":"Klára Felsövályi","orcid":null,"position":3,"is_corresponding":false},{"id":515283,"name":"Jennifer Fuller","orcid":"0000-0001-6609-8715","position":4,"is_corresponding":false},{"id":277975,"name":"Timothy Cardozo","orcid":"0000-0002-0643-4497","position":5,"is_corresponding":false},{"id":515281,"name":"Eric Ni","orcid":"0000-0002-4530-0707","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-18T23:12:31.053776Z","pmid":"32149277","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}