{"doi":"10.4155/bio-2020-0033","title":"A UHPLC–MS/MS Method to Determine FLZ Major Active Metabolites in Human Plasma: Application to a Pharmacokinetic Study","abstract":null,"journal":"Bioanalysis","year":2020,"id":661072,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1259303,"name":"Huanhuan Wang","orcid":"0000-0003-0452-9588","position":1,"is_corresponding":false},{"id":1169275,"name":"Rui Chen","orcid":"0000-0002-0541-1824","position":2,"is_corresponding":false},{"id":1725708,"name":"Ji Jiang","orcid":null,"position":3,"is_corresponding":false},{"id":947179,"name":"Qian Zhao","orcid":"0000-0003-0304-8854","position":4,"is_corresponding":false},{"id":733529,"name":"Pei Hu","orcid":"0000-0001-7724-6859","position":5,"is_corresponding":false},{"id":461505,"name":"Teng Wang","orcid":"0000-0002-9925-6297","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A UHPLC–MS/MS Method to Determine FLZ Major Active Metabolites in Human Plasma: Application to a Pharmacokinetic Study","abstract":"Aim: FLZ, a novel promising dopamine neuroprotective agent, is designed to treat Parkinson's disease. F7G and F21G are FLZ major active Phase II metabolites whose exposure are nearly 100-times higher than FLZ, may chiefly produce effectiveness in human. Measurement of F7G and F21G in plasma samples is critical for investigating its pharmacokinetics in clinical studies. Methodology & results: Plasma samples were extracted by SPE method and then analyzed by a newly established ultra-UHPLC–MS/MS method. Conclusion: For the first time, a reliable and robust bioanalytical method for F7G and F21G detection was successfully applied in a first-in-human study.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32469612","pmcid":null,"openalex_id":"https://openalex.org/W3030862454","authors":[],"funders":[{"funder_name":"Chinese National Major Project for New Drug Innovation","grant_id":"2019ZX09734001","title":null},{"funder_name":"Drug Development and Application of Chinese Pharmacological Society","grant_id":"2019DL001","title":null},{"funder_name":"Jinqiao Project of Beijing Association of Science and Technology","grant_id":"ZZ19005","title":null},{"funder_name":"Key Laboratory of Clinical PK and PD Investigation for Innovative Drugs","grant_id":"2016-I2M-1-010","title":null}],"total_grants":4,"fwci":0.0942,"citation_percentile":0.34639008,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.4155/bio-2020-0033","host_type":"publisher"},{"url":"https://doi.org/10.4155/bio-2020-0033","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32469612","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Analytical Chemistry and Chromatography","Metabolomics and Mass Spectrometry Studies"],"mesh_terms":["Acrylamides","Caffeic Acids","Chromatography, High Pressure Liquid","Humans","Molecular Conformation","Stereoisomerism","Neuroprotective Agents","Tandem Mass Spectrometry"],"keywords":["Pharmacokinetics","Active metabolite","Human plasma","Chemistry","Chromatography","Bioanalysis","Metabolite","Plasma concentration","Plasma","Pharmacology","Biochemistry","Medicine","Metabolites","Parkinson's Disease","Uhplc–ms/ms"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T10:20:50.665336Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}