{"doi":"10.4149/neo_2015_033","title":"Clinical significance of ERG rearrangement subtype and its association with increased p53 expression in Japanese and German prostate cancer","abstract":null,"journal":"Neoplasma","year":2015,"id":617861,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1593567,"name":"T. HARA","orcid":null,"position":1,"is_corresponding":false},{"id":1593569,"name":"K. IKEMOTO","orcid":null,"position":2,"is_corresponding":false},{"id":1593570,"name":"A. OGA","orcid":null,"position":3,"is_corresponding":false},{"id":1593572,"name":"K. KOBAYASHI","orcid":null,"position":4,"is_corresponding":false},{"id":1593574,"name":"Y. KAWAI","orcid":null,"position":5,"is_corresponding":false},{"id":1593575,"name":"H. MATSUMOTO","orcid":null,"position":6,"is_corresponding":false},{"id":1593576,"name":"K. NAGAO","orcid":null,"position":7,"is_corresponding":false},{"id":1593577,"name":"K. SASAKI","orcid":null,"position":8,"is_corresponding":false},{"id":1593579,"name":"V. GKOLEIZAKIS","orcid":null,"position":9,"is_corresponding":false},{"id":1593582,"name":"J. FICHTNER","orcid":null,"position":10,"is_corresponding":false},{"id":1593584,"name":"H. MATSUYAMA","orcid":null,"position":11,"is_corresponding":false},{"id":1593565,"name":"J. NISHIJIMA","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinical significance of ERG rearrangement subtype and its association with increased p53 expression in Japanese and German prostate cancer","abstract":"UNLABELLED: This study investigated differences in prevalence of the androgen-regulated transmembrane protease serine 2 (TMPRSS2) and ETS transcription factor family member, v-ets erythroblastosis virus E26 oncogene homolog (ERG) fusion gene (TMPRSS2-ERG fusions) in clinically localized prostate cancer Japanese and German patients. A total of 105 specimens, including 69 Japanese and 36 German patients, were collected. The status of TMPRSS2-ERG fusion was determined by fluorescence in situ hybridization, and correlations of the TMPRSS2-ERG fusion with clinicopathological characteristics and immunohistochemistry were studied. Gene fusions were identified in 20% (14/69) of Japanese and 53% (19/36) of German patients (P < 0.001). The difference in the type of gene fusion between the two ethnic groups was statistically significant (P=0.024). Overexpression of ERG protein was significantly associated with gene fusion. Biochemical recurrence was significantly higher in patients with ERG overexpression than in those without, and not related to TMPRSS2-ERG fusion status. Interestingly, two types of gene fusions (deletion and increase of copy number) were significantly associated with increased p53 expression (P = 0.005). Association of specific gene fusions harboring higher genomic alterations with p53 expression levels suggests that p53 mutation might drive more aggressive arrangements of TMPRSS2-ERG fusion in prostate cancer. KEYWORDS: ERG, p53, prostate cancer, TMPRSS2-ERG fusion.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25591593","pmcid":null,"openalex_id":"https://openalex.org/W2050815876","authors":[],"funders":[],"total_grants":0,"fwci":1.4164,"citation_percentile":0.82555116,"influential_citations":0,"citation_trend":[{"year":2015,"count":2},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2023,"count":1},{"year":2026,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"http://www.elis.sk/download_file.php?product_id=4131&session_id=fvrrqvcc4vsk9c6611pii5kis6","host_type":"journal"},{"url":"http://www.elis.sk/download_file.php?product_id=4131&session_id=fvrrqvcc4vsk9c6611pii5kis6","host_type":"publisher"},{"url":"https://doi.org/10.4149/neo_2015_033","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25591593","host_type":"repository"}],"fields_of_study":["Prostate Cancer Treatment and Research","Prostate Cancer Diagnosis and Treatment","Melanoma and MAPK Pathways"],"mesh_terms":[],"keywords":["TMPRSS2","Erg","Fusion gene","Prostate cancer","Cancer research","Biology","Oncogene Proteins","Immunohistochemistry","Gene","Cancer","Genetics","Medicine","Internal medicine","Regulation of gene expression","Immunology","Coronavirus disease 2019 (COVID-19)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T02:48:15.288186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}