{"doi":"10.4103/jpbs.jpbs_1230_25","title":"Efficacy of Silver Diamine Fluoride and Nanosilver Fluoride in Preventing Caries: A Comparative Study","abstract":"<jats:sec>\n                    <jats:title>Background:</jats:title>\n                    <jats:p>Dental caries remains a prevalent global health issue, particularly among children. Silver diamine fluoride (SDF) is a well-established caries-arresting agent, while nanosilver fluoride (NSF), a newer formulation combining silver nanoparticles and fluoride, offers potential antibacterial and remineralizing benefits. However, comparative evidence on their caries-preventive efficacy remains limited.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:</jats:title>\n                    <jats:p>\n                      A randomized, double-blind, controlled clinical trial was conducted involving 90 caries-active children aged 6 to 9 years. Participants were randomly assigned to three groups (\n                      <jats:italic toggle=\"yes\">n</jats:italic>\n                      = 30 each): Group A received 38% SDF, Group B received NSF, and Group C received distilled water (control). Baseline caries experience was recorded using the DMFS index. Treatments were applied at baseline and after six months. Follow-up examinations were conducted at six and 12 months. Data were analyzed using ANOVA and\n                      <jats:italic toggle=\"yes\">post hoc</jats:italic>\n                      Tukey’s test with significance set at\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      &lt; 0.05.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:</jats:title>\n                    <jats:p>\n                      After 12 months, Group A (SDF) showed a mean increment of 0.8 ± 1.2 in DMFS, Group B (NSF) showed 1.1 ± 1.3, and Group C (control) showed 2.7 ± 1.5. The differences between Group A and Group C (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      &lt; 0.001) and between Group B and Group C (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      = 0.003) were statistically significant, while the difference between Group A and Group B was not (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      = 0.217).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:</jats:title>\n                    <jats:p>Both silver diamine fluoride and nanosilver fluoride were effective in preventing caries progression in high-risk children, with SDF showing marginally better efficacy. NSF appears to be a promising alternative with comparable outcomes.</jats:p>\n                  </jats:sec>","journal":"Journal of Pharmacy and Bioallied Sciences","year":2025,"id":643673,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1674866,"name":"Sameep Singh","orcid":null,"position":1,"is_corresponding":false},{"id":1172638,"name":"Neeti Mittal","orcid":"0000-0002-7866-5091","position":2,"is_corresponding":false},{"id":1674867,"name":"Bismay Singh","orcid":null,"position":3,"is_corresponding":false},{"id":1674868,"name":"Ashtha Arya","orcid":null,"position":4,"is_corresponding":false},{"id":742432,"name":"Preeti Patil","orcid":"0000-0003-2535-6890","position":5,"is_corresponding":false},{"id":1674869,"name":"Jnana Ranjan Swain","orcid":null,"position":6,"is_corresponding":false},{"id":1674865,"name":"Priyatam Karade","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Efficacy of Silver Diamine Fluoride and Nanosilver Fluoride in Preventing Caries: A Comparative Study","abstract":"<jats:sec>\n                    <jats:title>Background:</jats:title>\n                    <jats:p>Dental caries remains a prevalent global health issue, particularly among children. Silver diamine fluoride (SDF) is a well-established caries-arresting agent, while nanosilver fluoride (NSF), a newer formulation combining silver nanoparticles and fluoride, offers potential antibacterial and remineralizing benefits. However, comparative evidence on their caries-preventive efficacy remains limited.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:</jats:title>\n                    <jats:p>\n                      A randomized, double-blind, controlled clinical trial was conducted involving 90 caries-active children aged 6 to 9 years. Participants were randomly assigned to three groups (\n                      <jats:italic toggle=\"yes\">n</jats:italic>\n                      = 30 each): Group A received 38% SDF, Group B received NSF, and Group C received distilled water (control). Baseline caries experience was recorded using the DMFS index. Treatments were applied at baseline and after six months. Follow-up examinations were conducted at six and 12 months. Data were analyzed using ANOVA and\n                      <jats:italic toggle=\"yes\">post hoc</jats:italic>\n                      Tukey’s test with significance set at\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      &lt; 0.05.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:</jats:title>\n                    <jats:p>\n                      After 12 months, Group A (SDF) showed a mean increment of 0.8 ± 1.2 in DMFS, Group B (NSF) showed 1.1 ± 1.3, and Group C (control) showed 2.7 ± 1.5. The differences between Group A and Group C (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      &lt; 0.001) and between Group B and Group C (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      = 0.003) were statistically significant, while the difference between Group A and Group B was not (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                      = 0.217).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:</jats:title>\n                    <jats:p>Both silver diamine fluoride and nanosilver fluoride were effective in preventing caries progression in high-risk children, with SDF showing marginally better efficacy. NSF appears to be a promising alternative with comparable outcomes.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41522981","pmcid":"PMC12788558","openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc-sa","oa_locations":[{"url":"https://doi.org/10.4103/jpbs.jpbs_1230_25","host_type":"publisher"},{"url":"https://journals.lww.com/10.4103/jpbs.jpbs_1230_25","host_type":"publisher"},{"url":"https://doaj.org/article/858d25b3567f4c058a5da7d8a1c44059","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12788558/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12788558","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":[],"keywords":["Caries","Sdf","Nanosilver Fluoride"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T18:18:35.147963Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}