{"doi":"10.4103/irjcm.irjcm_2_24","title":"The Rate of Anti-measles Immunoglobulin M Positivity among Children with Skin Rash and Fever in Diyala Province","abstract":"<jats:title>Abstract</jats:title>\n          <jats:sec>\n            <jats:title>Background:</jats:title>\n            <jats:p>Measles is an extremely contagious disease characterized by generalized maculopapular rash, fever, cough, coryza, and conjunctivitis. It is caused by the measles virus.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Objective:</jats:title>\n            <jats:p>The objective of this study was to explore the anti-measles immunoglobulin (Ig) M positivity rate among children with clinical suspicion of having measles.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Subjects and Methods:</jats:title>\n            <jats:p>This is a cross-sectional study carried out in Diyala Province, Iraq, from November/2020 to October/2021. A total of 425 blood samples were collected from children (≤14 years of age): 90 from patients who were clinically suspected as having measles (18 were vaccinated with measles vaccine and 72 were not); 270 from measles-vaccinated children, including those children who received all recommended vaccines in the Iraqi Expanded Program of Immunization (IEPI); and 65 from nonvaccinated children, including those children who received none of the vaccines in the IEPI. Enzyme-linked immunosorbent assay (ELISA) kits for the detection of anti-measles IgM were used.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Results:</jats:title>\n            <jats:p>The results found that 14 (15.6%) of clinically suspected children were positive for anti-measles IgM antibody versus 76 (84.4%) who were negative. Whereas, only one (1.5%) of the unvaccinated children was positive, and all vaccinated children were negative. Thus, clinically suspected patients had a significantly higher positivity rate compared to other study groups (<jats:italic toggle=\"yes\">P</jats:italic> = 0.0001). Similarly, the mean ± standard deviation of anti-measles IgM concentration was significantly higher compared to other study groups (<jats:italic toggle=\"yes\">P</jats:italic> = 0.0001).</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:</jats:title>\n            <jats:p>About one-sixth of patients clinically comparable to measles in Diyala Province actually had measles, most of them were unvaccinated, and the anti-measles IgM ELISA technique was a good marker for exploring measles cases.</jats:p>\n          </jats:sec>","journal":"Iraqi Journal of Community Medicine","year":2024,"id":637295,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1654623,"name":"Raghad E. Salman","orcid":null,"position":1,"is_corresponding":false},{"id":1654625,"name":"Mohammad K. Saleh","orcid":null,"position":2,"is_corresponding":false},{"id":1654627,"name":"Nadhim G. Noaman","orcid":null,"position":3,"is_corresponding":false},{"id":1654629,"name":"Alyaa Y. Ali","orcid":null,"position":4,"is_corresponding":false},{"id":1654631,"name":"Hiba H. Rashid","orcid":null,"position":5,"is_corresponding":false},{"id":1654633,"name":"Noor I. Zaidan","orcid":null,"position":6,"is_corresponding":false},{"id":1654621,"name":"Abdulrazak SH. Hasan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Rate of Anti-measles Immunoglobulin M Positivity among Children with Skin Rash and Fever in Diyala Province","abstract":"<jats:title>Abstract</jats:title>\n          <jats:sec>\n            <jats:title>Background:</jats:title>\n            <jats:p>Measles is an extremely contagious disease characterized by generalized maculopapular rash, fever, cough, coryza, and conjunctivitis. It is caused by the measles virus.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Objective:</jats:title>\n            <jats:p>The objective of this study was to explore the anti-measles immunoglobulin (Ig) M positivity rate among children with clinical suspicion of having measles.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Subjects and Methods:</jats:title>\n            <jats:p>This is a cross-sectional study carried out in Diyala Province, Iraq, from November/2020 to October/2021. A total of 425 blood samples were collected from children (≤14 years of age): 90 from patients who were clinically suspected as having measles (18 were vaccinated with measles vaccine and 72 were not); 270 from measles-vaccinated children, including those children who received all recommended vaccines in the Iraqi Expanded Program of Immunization (IEPI); and 65 from nonvaccinated children, including those children who received none of the vaccines in the IEPI. Enzyme-linked immunosorbent assay (ELISA) kits for the detection of anti-measles IgM were used.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Results:</jats:title>\n            <jats:p>The results found that 14 (15.6%) of clinically suspected children were positive for anti-measles IgM antibody versus 76 (84.4%) who were negative. Whereas, only one (1.5%) of the unvaccinated children was positive, and all vaccinated children were negative. Thus, clinically suspected patients had a significantly higher positivity rate compared to other study groups (<jats:italic toggle=\"yes\">P</jats:italic> = 0.0001). Similarly, the mean ± standard deviation of anti-measles IgM concentration was significantly higher compared to other study groups (<jats:italic toggle=\"yes\">P</jats:italic> = 0.0001).</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:</jats:title>\n            <jats:p>About one-sixth of patients clinically comparable to measles in Diyala Province actually had measles, most of them were unvaccinated, and the anti-measles IgM ELISA technique was a good marker for exploring measles cases.</jats:p>\n          </jats:sec>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37284641","pmcid":null,"openalex_id":"https://openalex.org/W4400266850","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.15964562,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by-nc-sa","oa_locations":[{"url":"https://doi.org/10.4103/irjcm.irjcm_2_24","host_type":"journal"},{"url":"https://doi.org/10.4103/irjcm.irjcm_2_24","host_type":"publisher"},{"url":"https://journals.lww.com/10.4103/IRJCM.IRJCM_2_24","host_type":"publisher"}],"fields_of_study":["Virology and Viral Diseases","SARS-CoV-2 and COVID-19 Research","Vaccine Coverage and Hesitancy"],"mesh_terms":[],"keywords":["Measles","Rash","Medicine","Maculopapular rash","Measles vaccine","Measles virus","Vaccination","Immunization","Antibody","Immunology","Pediatrics","Dermatology","C11orf95","Ependymoma","MAML2","Myogenic","ZFTA"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T18:41:44.432376Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}