{"doi":"10.4103/0973-1482.162120","title":"Sunitinib treatment of metastatic renal cell carcinoma in von Hippel-Lindau disease","abstract":"<jats:p>Von Hippel-Lindau disease (VHL) is a major heritable renal cell cancer (RCC) syndrome. 24-45% of VHL patients have a cumulative risk to develop RCC. The management of VHL has changed significantly as clinicians have learned how to best balance the risk of cancer dissemination while minimizing renal morbidity. Despite the improving management of this disease, there are no evidence-based guidelines of the treatment of localized and advanced RCC in VHL. Here, we describe a 39-year-old patient with VHL disease who developed metastatic RCC and received sunitinib with complete remission.</jats:p>","journal":"Journal of Cancer Research and Therapeutics","year":2015,"id":631662,"datarank":0.6470140377993444,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.35512751544104737,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.35512751544104737,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":6,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1545026,"name":"Ilya Tsimafeyeu","orcid":"0000-0002-7357-0392","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Sunitinib treatment of metastatic renal cell carcinoma in von Hippel-Lindau disease","abstract":"<jats:p>Von Hippel-Lindau disease (VHL) is a major heritable renal cell cancer (RCC) syndrome. 24-45% of VHL patients have a cumulative risk to develop RCC. The management of VHL has changed significantly as clinicians have learned how to best balance the risk of cancer dissemination while minimizing renal morbidity. Despite the improving management of this disease, there are no evidence-based guidelines of the treatment of localized and advanced RCC in VHL. Here, we describe a 39-year-old patient with VHL disease who developed metastatic RCC and received sunitinib with complete remission.</jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26881543","pmcid":null,"openalex_id":"https://openalex.org/W2301004672","authors":[],"funders":[],"total_grants":0,"fwci":0.3082,"citation_percentile":0.57774104,"influential_citations":0,"citation_trend":[{"year":2016,"count":2},{"year":2018,"count":1},{"year":2020,"count":2},{"year":2022,"count":1}],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://doi.org/10.4103/0973-1482.162120","host_type":"journal"},{"url":"https://doi.org/10.4103/0973-1482.162120","host_type":"publisher"},{"url":"https://journals.lww.com/01363817-201511040-00044","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26881543","host_type":"repository"}],"fields_of_study":["Cancer, Hypoxia, and Metabolism","Renal cell carcinoma treatment","Medical Imaging and Pathology Studies"],"mesh_terms":["Sunitinib","Adult","Antineoplastic Agents","Carcinoma, Renal Cell","von Hippel-Lindau Disease","Humans","Indoles","Kidney Neoplasms","Male","Prognosis","Pyrroles"],"keywords":["Sunitinib","Renal cell carcinoma","Medicine","Von Hippel–Lindau disease","Disease","Oncology","Internal medicine","Cancer","Kidney cancer","Kidney disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T00:21:02.068202Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}