{"doi":"10.4103/0973-1482.155975","title":"Lac dye as a potential anti-neoplastic agent","abstract":"<jats:sec>\n                    <jats:title>Objective:</jats:title>\n                    <jats:p>Certain anthraquinone compounds are effectively used for treatment of cancer. The present study describes the inhibitory activity of lac dye, a mixture of polyhydroxy anthraquinone compounds (Laccaic acid A, B, C, D and E), produced by the Indian lac insect, Kerria lacca (Kerr).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:</jats:title>\n                    <jats:p>In vitro testing for anticancer activity of lac dye was done at four concentrations (10, 20, 40, 80 μg/ml) on ten human malignant cell lines including six human leukemia cell lines, U973, Raji, K562, Jurkat, MOLT 4 and HL60 using SRB assay.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion:</jats:title>\n                    <jats:p>Both crimson and yellow lac dye inhibits proliferation of Human leukemia cell lines, Raji, U937, K562, HL60 and Jurkat, therefore can be considered as a potential anticancer agent for leukemia.</jats:p>\n                  </jats:sec>","journal":"Journal of Cancer Research and Therapeutics","year":2016,"id":623020,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1610008,"name":"Sanjeev Kumar Ranjan","orcid":null,"position":1,"is_corresponding":false},{"id":1610010,"name":"Dev Mani Pandey","orcid":null,"position":2,"is_corresponding":false},{"id":1610012,"name":"Kewal Krishan Sharma","orcid":null,"position":3,"is_corresponding":false},{"id":1610013,"name":"Rangnathan Ramani","orcid":null,"position":4,"is_corresponding":false},{"id":1610006,"name":"Gulsaz Shamim","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Lac dye as a potential anti-neoplastic agent","abstract":"<jats:sec>\n                    <jats:title>Objective:</jats:title>\n                    <jats:p>Certain anthraquinone compounds are effectively used for treatment of cancer. The present study describes the inhibitory activity of lac dye, a mixture of polyhydroxy anthraquinone compounds (Laccaic acid A, B, C, D and E), produced by the Indian lac insect, Kerria lacca (Kerr).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:</jats:title>\n                    <jats:p>In vitro testing for anticancer activity of lac dye was done at four concentrations (10, 20, 40, 80 μg/ml) on ten human malignant cell lines including six human leukemia cell lines, U973, Raji, K562, Jurkat, MOLT 4 and HL60 using SRB assay.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion:</jats:title>\n                    <jats:p>Both crimson and yellow lac dye inhibits proliferation of Human leukemia cell lines, Raji, U937, K562, HL60 and Jurkat, therefore can be considered as a potential anticancer agent for leukemia.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27461693","pmcid":null,"openalex_id":"https://openalex.org/W2498798730","authors":[],"funders":[],"total_grants":0,"fwci":0.6567,"citation_percentile":0.70088961,"influential_citations":0,"citation_trend":[{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2023,"count":2},{"year":2024,"count":2}],"oa_status":"gold","license":"cc-by-nc-sa","oa_locations":[{"url":"https://doi.org/10.4103/0973-1482.155975","host_type":"journal"},{"url":"https://doi.org/10.4103/0973-1482.155975","host_type":"publisher"},{"url":"https://journals.lww.com/01363817-201612020-00104","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27461693","host_type":"repository"},{"url":"https://doaj.org/article/a05abe3de14d4c8bacdd680ce9d7fa37","host_type":"repository"}],"fields_of_study":["Synthesis and Biological Activity","Seaweed-derived Bioactive Compounds","Bioactive Compounds and Antitumor Agents","Antineoplastic Agents","Azo Compounds","Cell Line, Tumor","Cell Proliferation","Humans"],"mesh_terms":["Antineoplastic Agents","Azo Compounds","Humans","Cell Line, Tumor","Cell Proliferation"],"keywords":["HL60","Jurkat cells","K562 cells","Raji cell","Leukemia","Cell culture","Anthraquinone","Chemistry","In vitro","Anthraquinones","Biochemistry","Biology","Molecular biology","Botany","Immunology","Organic chemistry","T cell"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T22:01:46.402381Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}