{"doi":"10.4103/0019-5154.74531","title":"Study of reservoir effect of clobetasol propionate cream in an experimental animal model using histamine-induced wheal suppression test","abstract":null,"journal":"Indian Journal of Dermatology","year":2010,"id":666461,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":616670,"name":"Farida Ahmad","orcid":null,"position":1,"is_corresponding":false},{"id":1740440,"name":"SatyendraK Singh","orcid":null,"position":2,"is_corresponding":false},{"id":295150,"name":"Anil Kumar","orcid":"0000-0001-5242-1323","position":3,"is_corresponding":false},{"id":1740439,"name":"Afroz Abidi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Study of reservoir effect of clobetasol propionate cream in an experimental animal model using histamine-induced wheal suppression test","abstract":"BACKGROUND: Topical corticosteroids used in various dermatological diseases several times a day led to an increase risk of side effects. By demonstrating a significant reservoir of corticosteroids in the stratum corneum, one can maximize their efficacy and safety as therapeutic agents. AIM: The study was designed to demonstrate a reservoir of topically applied corticosteroid clobetasol propionate cream experimentally in rabbits using histamine-induced wheal suppression test. MATERIALS AND METHODS: The work was carried out on albino rabbits, as rabbit skin is akin to human skin, using a topical steroid. The topical steroid clobetasol propionate 0.05% cream was applied on the back of rabbit, and after 1-h occlusion histamine-induced wheal suppression test was performed and wheal area measured at 10 min till day 7. Statistical analysis was done by ANOVA followed by \"Post Hoc\" test. RESULTS: Maximum wheal suppression was seen on day 1 (P < 0.001). Interday comparison of mean wheal size showed no significant difference (P > 0.05) on day 2, 3, and 4 as compared to day 1. Day 5-7 show highly significant difference (P < 0.001) as compared to day 1, thereby suggesting that the reservoir effect of topical clobetasol propionate 0.05% cream persisted till day 4. CONCLUSIONS: This work demonstrated that histamine-induced wheal by the topical steroid clobetasol propionate 0.05% cream was suppressed till day 4, indicating that the reservoir of topical corticosteroid persisted till day 4.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21430883","pmcid":"PMC3051290","openalex_id":"https://openalex.org/W2020643074","authors":[],"funders":[],"total_grants":0,"fwci":0.5404,"citation_percentile":0.58732277,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by-nc-sa","oa_locations":[{"url":"https://doi.org/10.4103/0019-5154.74531","host_type":"journal"},{"url":"https://doi.org/10.4103/0019-5154.74531","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21430883","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3051290","host_type":"repository"},{"url":"https://doaj.org/article/ccf9c66fe4c045c08395ab0158443a41","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3051290","host_type":"Europe_PMC"}],"fields_of_study":["Advancements in Transdermal Drug Delivery","Dermatology and Skin Diseases","Allergic Rhinitis and Sensitization"],"mesh_terms":[],"keywords":["Clobetasol propionate","Medicine","Histamine","Topical steroid","Corticosteroid","Stratum corneum","Pharmacology","Dermatology","Internal medicine","Pathology","Reservoir","Topical Corticosteroid","Wheal Suppression"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T14:30:20.368105Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}