{"doi":"10.4088/jcp.23m15056","title":"A Pilot Study of High-Frequency Transcranial Magnetic Stimulation for Bipolar Depression","abstract":"Objective: Repetitive transcranial magnetic stimulation (rTMS) is a standard treatment approach for major depressive disorder.There is growing clinical experience to support the use of high-frequency left-sided rTMS in bipolar depression.This study collected open-label safety and effectiveness data in a sample of patients with bipolar depression.Methods: Thirty-one adults (13 male/ 18 female; mean age: 42.2 [14.3] years) with bipolar (I or II) depression verified by DSM-5 criteria were recruited at Sheppard Pratt and Mayo Clinic between August 2017 and February 2020 for rTMS.Standardized treatment protocols employed 6 weeks of 10-Hz rTMS to the left dorsolateral prefrontal cortex at 120% of motor threshold with 3,000 pulses per session in 4-second trains with intertrain intervals of 26 seconds.All patients were treated concurrently with a mood stabilizer.The primary outcome measure was the Montgomery-Asberg Depression Rating Scale (MADRS).Response and remission were defined as MADRS score reductions of 50% or score <10, respectively.We examined response, remission, and potential contributing factors with multivariate and logistic regression models. Results:The majority of patients with bipolar depression reached response (n = 27; 87.1%) and remission (n = 23; 74.2%).Older age and concurrent treatment with lithium were associated with higher MADRS scores throughout the treatment course (0.1 0.05, P = .05;4.05 1.27, P = .003,respectively).Concurrent treatment with lamotrigine was associated with lower MADRS scores (-3.48 1.26, P = .01).Treatment with rTMS was safe and well tolerated.There were no completed suicides, induced manic episodes, or other serious adverse events. Conclusion:Although preliminary, the present findings are encouraging regarding the safety and effectiveness of 10-Hz rTMS for bipolar depression.","journal":"The Journal of Clinical Psychiatry","year":2024,"id":446796,"datarank":0.309103042134341,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.01721651977604395,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.01721651977604395,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":6,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.86,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02640950"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":323222,"name":"Eric L. Goldwaser","orcid":"0000-0002-9676-9230","position":1,"is_corresponding":false},{"id":294680,"name":"Paul E. Croarkin","orcid":"0000-0001-6843-6503","position":2,"is_corresponding":false},{"id":241935,"name":"Jennifer R. Geske","orcid":"0000-0002-7341-1535","position":3,"is_corresponding":false},{"id":1006959,"name":"Allison LeMahieu","orcid":"0000-0003-1554-795X","position":4,"is_corresponding":false},{"id":1264437,"name":"Jennifer Sklar","orcid":null,"position":5,"is_corresponding":false},{"id":431816,"name":"Simon Kung","orcid":"0000-0002-2959-8312","position":6,"is_corresponding":false},{"id":586436,"name":"Scott T. Aaronson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T02:01:54.980444Z","pmid":"38780536","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}