{"doi":"10.4088/jcp.20l13353","title":"Clinical Trials With Suicidal Individuals Can Be Conducted Safely","abstract":"To the Editor: We applaud the recent report from Iltis and colleagues 1 addressing the issue of exclusion of suicidal patients from clinical trials for depression. Suicide rates in the United States have increased 33% since 1999, 2 partly due to the lack of appropriate treatments for suicidal individuals; clozapine is the only medication approved for suicidal behavior, and, as of the writing of this letter, no medications have been approved to treat suicidal thoughts. In addition, as Iltis and colleagues highlight, suicidal individuals are typically excluded from clinical trials for depression, so it is unclear which of our current medications are effective for treating these most vulnerable patients. Furthermore, suicidal patients are often excluded from non-depression clinical trials, including those for substance dependence, anxiety, or schizophrenia, further compounding health inequities. Consequently, clinicians have few evidence-based treatments for the 9 million Americans who consider suicide each year.","journal":"The Journal of Clinical Psychiatry","year":2020,"id":113699,"datarank":0.27560421784785466,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.06766006367987104,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.06766006367987104,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02543983"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":283158,"name":"Lawrence T. Park","orcid":"0000-0002-6570-686X","position":1,"is_corresponding":false},{"id":275343,"name":"Maryland Pao","orcid":"0000-0002-6987-2611","position":2,"is_corresponding":false},{"id":230008,"name":"Carlos A. Zarate","orcid":"0000-0003-4442-7412","position":3,"is_corresponding":false},{"id":244705,"name":"Elizabeth D. Ballard","orcid":"0000-0001-5304-0127","position":0,"is_corresponding":true}],"reference_count":7,"raw_metadata":null,"created_at":"2026-07-18T23:13:25.964732Z","pmid":"32757505","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}