{"doi":"10.4081/monaldi.2021.1710","title":"A review of the presentation and outcome of Takotsubo cardiomyopathy in COVID-19","abstract":"<jats:p>Although the most frequent presentation of the novel Coronavirus disease-2019 (COVID-19) is a respiratory syndrome, cardiac involvement is being increasingly recognized. One such entity is takotsubo cardiomyopathy. We sought to review the various cases of takotsubo cardiomyopathy reported during the COVID-19 pandemic and consolidate the information available on its clinical features, evaluation and treatment. We performed a PubMed search using the MeSH terms “Takotsubo Cardiomyopathy” or “Stress Cardiomyopathy” and “COVID-19”, and identified 16 case reports, two case series, and one retrospective cohort study. There was a total of 24 reported patients with COVID-19 infection, who developed takotsubo cardiomyopathy, and two patients without COVID-19 who developed takotsubo cardiomyopathy due to the emotional stress associated with the global pandemic. The mean age of the patients was 67.19 years (SD 15.83) and 16(59.3%) were women. Chest pain was reported in only ten patients (38.46 %) and ST-elevation was seen in 11 patients (42.3%). While most patients had typical takotsubo cardiomyopathy, four patients had inverted(reverse) takotsubo cardiomyopathy, two had bi-ventricular involvement, one had median takotsubo and another had global takotsubo with apical sparing variant. Most patients had a positive outcome with complete or near-complete reversal of cardiac dysfunction at the time of discharge. Five deaths (19.23%) were reported. Takotsubo cardiomyopathy is a rare, but increasingly reported reversible cardiomyopathy that can be seen in patients with COVID-19 infection and the diagnosis must be actively sought for in these patients.</jats:p>","journal":"Monaldi Archives for Chest Disease","year":2021,"id":601425,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":628880,"name":"Amos Lal","orcid":"0000-0002-0021-2033","position":1,"is_corresponding":false},{"id":1318200,"name":"Ajay Mishra","orcid":"0000-0001-8201-4067","position":2,"is_corresponding":false},{"id":1239373,"name":"Kevin John","orcid":"0000-0002-2299-0434","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A review of the presentation and outcome of Takotsubo cardiomyopathy in COVID-19","abstract":"<jats:p>Although the most frequent presentation of the novel Coronavirus disease-2019 (COVID-19) is a respiratory syndrome, cardiac involvement is being increasingly recognized. One such entity is takotsubo cardiomyopathy. We sought to review the various cases of takotsubo cardiomyopathy reported during the COVID-19 pandemic and consolidate the information available on its clinical features, evaluation and treatment. We performed a PubMed search using the MeSH terms “Takotsubo Cardiomyopathy” or “Stress Cardiomyopathy” and “COVID-19”, and identified 16 case reports, two case series, and one retrospective cohort study. There was a total of 24 reported patients with COVID-19 infection, who developed takotsubo cardiomyopathy, and two patients without COVID-19 who developed takotsubo cardiomyopathy due to the emotional stress associated with the global pandemic. The mean age of the patients was 67.19 years (SD 15.83) and 16(59.3%) were women. Chest pain was reported in only ten patients (38.46 %) and ST-elevation was seen in 11 patients (42.3%). While most patients had typical takotsubo cardiomyopathy, four patients had inverted(reverse) takotsubo cardiomyopathy, two had bi-ventricular involvement, one had median takotsubo and another had global takotsubo with apical sparing variant. Most patients had a positive outcome with complete or near-complete reversal of cardiac dysfunction at the time of discharge. Five deaths (19.23%) were reported. Takotsubo cardiomyopathy is a rare, but increasingly reported reversible cardiomyopathy that can be seen in patients with COVID-19 infection and the diagnosis must be actively sought for in these patients.</jats:p>","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33759445","pmcid":null,"openalex_id":"https://openalex.org/W3139236829","authors":[],"funders":[],"total_grants":0,"fwci":3.6549,"citation_percentile":0.94349417,"influential_citations":0,"citation_trend":[{"year":2021,"count":5},{"year":2022,"count":12},{"year":2023,"count":6},{"year":2024,"count":2}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://www.monaldi-archives.org/macd/article/download/1710/1214","host_type":"journal"},{"url":"https://www.monaldi-archives.org/macd/article/download/1710/1214","host_type":"publisher"},{"url":"https://www.monaldi-archives.org/index.php/macd/article/download/1710/1214","host_type":"publisher"},{"url":"https://doi.org/10.4081/monaldi.2021.1710","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33759445","host_type":"repository"},{"url":"https://doaj.org/article/9128969b48254bff80008eb823c99039","host_type":"repository"}],"fields_of_study":["Takotsubo Cardiomyopathy and Associated Phenomena","Long-Term Effects of COVID-19","Cardiac Structural Anomalies and Repair","Aged","COVID-19","Echocardiography","Female","Humans","Pandemics","Retrospective Studies","SARS-CoV-2","Takotsubo Cardiomyopathy"],"mesh_terms":["COVID-19","SARS-CoV-2","Aged","Echocardiography","Female","Humans","Retrospective Studies","Takotsubo Cardiomyopathy","Pandemics"],"keywords":["Cardiomyopathy","Medicine","Internal medicine","Chest pain","Cardiology","Retrospective cohort study","Presentation (obstetrics)","Coronavirus disease 2019 (COVID-19)","Heart failure","Disease","Surgery"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T16:19:16.656352Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}