{"doi":"10.4049/jimmunol.91.2.197","title":"The Effects of Treatment with the Emulsions of Ragweed Extract on Antibody Titers","abstract":"<jats:title>Summary</jats:title>\n               <jats:p>The skin-sensitizing and hemagglutinating antibody titers of most ragweed hay fever patients rise after an injection of emulsified ragweed extract reaching a peak at 3 to 6 weeks and showing a gradual decline by the end of 12 weeks. The least sensitive group of patients who received the highest dosage (10,000 PNU) showed no significant changes in skin-sensitizing antibody titer, but did respond with increased hemagglutinating and blocking antibody titers. All groups of patients showed a rise in blocking antibody after treatment reaching a peak at approximately 6 weeks. The group that received 10,000 PNU remained essentially unchanged from the 6th to 12th weeks whereas those that received 1000, 2500, or 5000 PNU showed a decrease in titer. Patients who received two injections of emulsified ragweed extract showed further increases of all antibody titers after the second injection.</jats:p>","journal":"The Journal of Immunology","year":1963,"id":590435,"datarank":1.0933054108930944,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.7336211199733388,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.7336211199733388,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":8,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1510684,"name":"William B Sherman","orcid":null,"position":1,"is_corresponding":false},{"id":1510683,"name":"John T Connell","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Effects of Treatment with the Emulsions of Ragweed Extract on Antibody Titers","abstract":"Summary The skin-sensitizing and hemagglutinating antibody titers of most ragweed hay fever patients rise after an injection of emulsified ragweed extract reaching a peak at 3 to 6 weeks and showing a gradual decline by the end of 12 weeks. The least sensitive group of patients who received the highest dosage (10,000 PNU) showed no significant changes in skin-sensitizing antibody titer, but did respond with increased hemagglutinating and blocking antibody titers. All groups of patients showed a rise in blocking antibody after treatment reaching a peak at approximately 6 weeks. The group that received 10,000 PNU remained essentially unchanged from the 6th to 12th weeks whereas those that received 1000, 2500, or 5000 PNU showed a decrease in titer. Patients who received two injections of emulsified ragweed extract showed further increases of all antibody titers after the second injection.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26657633","pmcid":null,"openalex_id":"https://openalex.org/W4313375248","authors":[],"funders":[],"total_grants":0,"fwci":1.992,"citation_percentile":0.88428499,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.4049/jimmunol.91.2.197","host_type":"journal"}],"fields_of_study":["Insect and Pesticide Research","Healthcare and Venom Research","Toxin Mechanisms and Immunotoxins"],"mesh_terms":[],"keywords":["Ragweed","Titer","Hay fever","Antibody titer","Antibody","Blocking antibody","Medicine","Antibody response","Immunology","Allergy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T21:07:15.540850Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}