{"doi":"10.4049/jimmunol.2300575","title":"The Marginal Zone B Cell Compartment and T Cell–independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1","abstract":"The prototypic IFN-inducible transcription factor, IRF1, not only controls inflammatory gene expression but also regulates T cell and macrophage fate specification and function. Using bone marrow chimeras (80% B6.129S2-Ighmtm1Cgn/J [µMT] + 20% B6.129S2-Irf1tm1Mak/J [Irf1-/-]), we show that IRF1 expression in B cells is required for marginal zone B (MZB) cell development and T cell-independent Ab responses. Although IFNs can induce IRF1 expression in MZB precursors, deletion of the IFN-γR (C57BL/6J [B6], B6.129S7-Ifngr1tm1Agt/J) or IFN-αR (B6[Cg]-Ifnar1tm1Agt/J) did not affect MZB cell development. Instead, BCR and TLR signals promote IRF1 expression and nuclear translocation in MZB cell precursors. In turn, IRF1 is required for Notch2-dependent gene expression in BCR- and TLR-stimulated transitional B cells and development of the MZB cell compartment. Thus, IRF1 regulates MZB-driven T cell-independent Ab responses by regulating Notch programming in MZB precursors and facilitating commitment of these cells to the MZB lineage.","journal":"The Journal of Immunology","year":2024,"id":441367,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1253865,"name":"Eddie‐Williams Owiredu","orcid":"0000-0003-4499-0678","position":1,"is_corresponding":false},{"id":293771,"name":"Alexander F. Rosenberg","orcid":null,"position":2,"is_corresponding":false},{"id":273531,"name":"Aarón Silva-Sánchez","orcid":"0000-0002-1882-2534","position":3,"is_corresponding":false},{"id":273532,"name":"Troy D. Randall","orcid":"0000-0003-0643-0311","position":4,"is_corresponding":false},{"id":292531,"name":"John F. Kearney","orcid":"0000-0003-2569-2560","position":5,"is_corresponding":false},{"id":442365,"name":"Frances E. Lund","orcid":"0000-0003-3083-1246","position":6,"is_corresponding":false},{"id":632109,"name":"Jessica N. Peel","orcid":"0000-0002-1894-8882","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T02:01:06.281460Z","pmid":"39451043","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}