{"doi":"10.4049/jimmunol.2300270","title":"PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection","abstract":"Protein arginine methyltransferases (PRMTs) modify diverse protein targets and regulate numerous cellular processes; yet, their contributions to individual effector T cell responses during infections are incompletely understood. In this study, we identify PRMT5 as a critical regulator of CD4+ T follicular helper cell (Tfh) responses during influenza virus infection in mice. Conditional PRMT5 deletion in murine T cells results in an almost complete ablation of both Tfh and T follicular regulatory populations and, consequently, reduced B cell activation and influenza-specific Ab production. Supporting a potential mechanism, we observe elevated surface expression of IL-2Rα on non-T regulatory effector PRMT5-deficient T cells. Notably, IL-2 signaling is known to negatively impact Tfh differentiation. Collectively, our findings identify PRMT5 as a prominent regulator of Tfh programming, with potential causal links to IL-2 signaling.","journal":"The Journal of Immunology","year":2024,"id":475479,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":302669,"name":"Stephanie A. Amici","orcid":"0000-0002-3335-760X","position":1,"is_corresponding":false},{"id":1312509,"name":"Sadaf Farsi","orcid":"0009-0007-7034-0747","position":2,"is_corresponding":false},{"id":713007,"name":"Madeline P. Cutcliffe","orcid":"0000-0001-6718-9862","position":3,"is_corresponding":false},{"id":1312510,"name":"Bella Lee","orcid":"0000-0002-4848-7829","position":4,"is_corresponding":false},{"id":304129,"name":"Chan‐Wang Jerry Lio","orcid":"0000-0003-3876-6741","position":5,"is_corresponding":false},{"id":1312511,"name":"H. Wu","orcid":"0000-0001-8000-8982","position":6,"is_corresponding":false},{"id":232994,"name":"Mireia Guerau‐de‐Arellano","orcid":"0000-0002-0600-4593","position":7,"is_corresponding":false},{"id":264329,"name":"Kenneth J. Oestreich","orcid":"0000-0002-3004-072X","position":8,"is_corresponding":false},{"id":264328,"name":"Kaitlin A. Read","orcid":"0000-0001-5704-5064","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T02:06:21.071690Z","pmid":"38436421","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}