{"doi":"10.4049/jimmunol.2200916","title":"IL-33 Induces Cellular and Exosomal miR-146a Expression as a Feedback Inhibitor of Mast Cell Function","abstract":"IL-33 is an inflammatory cytokine that promotes allergic disease by activating group 2 innate lymphoid cells, Th2 cells, and mast cells. IL-33 is increased in asthmatics, and its blockade suppresses asthma-like inflammation in mouse models. Homeostatic control of IL-33 signaling is poorly understood. Because the IL-33 receptor, ST2, acts via cascades used by the TLR family, similar feedback mechanisms may exist. MicroRNA (miR)-146a is induced by LPS-mediated TLR4 signaling and serves as a feedback inhibitor. Therefore, we explored whether miR-146a has a role in IL-33 signaling. IL-33 induced cellular and exosomal miR-146a expression in mouse bone marrow-derived mast cells (BMMCs). BMMCs transfected with a miR-146a antagonist or derived from miR-146a knockout mice showed enhanced cytokine expression in response to IL-33, suggesting that miR-146a is a negative regulator of IL-33-ST2 signaling. In vivo, miR-146a expression in plasma exosomes was elevated after i.p. injection of IL-33 in wild-type but not mast cell-deficient KitW-sh/W-sh mice. Finally, KitW-sh/W-sh mice acutely reconstituted with miR-146a knockout BMMCs prior to IL-33 challenge had elevated plasma IL-6 levels compared with littermates receiving wild-type BMMCs. These results support the hypothesis that miR-146a is a feedback regulator of IL-33-mediated mast cell functions associated with allergic disease.","journal":"The Journal of Immunology","year":2024,"id":452716,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":433078,"name":"Amina Abdul Qayum","orcid":null,"position":1,"is_corresponding":false},{"id":407049,"name":"Daniel Abebayehu","orcid":"0000-0002-6837-3028","position":2,"is_corresponding":false},{"id":450965,"name":"Heather L. Caslin","orcid":"0000-0002-7471-6779","position":3,"is_corresponding":false},{"id":452060,"name":"Jordan Dailey","orcid":null,"position":4,"is_corresponding":false},{"id":890940,"name":"Aditya Kotha","orcid":null,"position":5,"is_corresponding":false},{"id":781963,"name":"Jason R. Burchett","orcid":null,"position":6,"is_corresponding":false},{"id":450964,"name":"Sydney Ann Kee","orcid":"0000-0002-1254-4828","position":7,"is_corresponding":false},{"id":743027,"name":"Tania D. Maldonado","orcid":"0009-0005-3529-0129","position":8,"is_corresponding":false},{"id":1218616,"name":"Boyang Ren","orcid":"0000-0002-4157-5199","position":9,"is_corresponding":false},{"id":461372,"name":"Wei Chao","orcid":"0000-0002-2505-1360","position":10,"is_corresponding":false},{"id":461371,"name":"Lin Zou","orcid":"0000-0003-0820-4246","position":11,"is_corresponding":false},{"id":431919,"name":"Tamara T. Haque","orcid":"0000-0003-4436-9558","position":12,"is_corresponding":false},{"id":450966,"name":"David B. Straus","orcid":"0000-0003-1989-8255","position":13,"is_corresponding":false},{"id":384854,"name":"John Ryan","orcid":"0000-0002-9203-5512","position":14,"is_corresponding":false},{"id":450962,"name":"Marcela T Taruselli","orcid":"0000-0002-7965-4335","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T02:02:54.415477Z","pmid":"38381001","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}