{"doi":"10.4049/jimmunol.2200778","title":"Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5","abstract":"The RNA-binding protein DEAD-box protein 5 (DDX5) is a polyfunctional regulator of gene expression, but its role in CD8+ T cell biology has not been extensively investigated. In this study, we demonstrate that deletion of DDX5 in murine CD8+ T cells reduced the differentiation of terminal effector, effector memory T, and terminal effector memory cells while increasing the generation of central memory T cells, whereas forced expression of DDX5 elicited the opposite phenotype. DDX5-deficient CD8+ T cells exhibited increased expression of genes that promote central memory T cell differentiation, including Tcf7 and Eomes. Taken together, these findings reveal a role for DDX5 in regulating the differentiation of effector and memory CD8+ T cell subsets in response to microbial infection.","journal":"The Journal of Immunology","year":2023,"id":374861,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9641,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":855515,"name":"William H. Wong","orcid":null,"position":1,"is_corresponding":false},{"id":854749,"name":"Priscilla Yao","orcid":"0000-0002-4700-6851","position":2,"is_corresponding":false},{"id":238814,"name":"Nadia S. Kurd","orcid":null,"position":3,"is_corresponding":false},{"id":236073,"name":"Tiffani Tysl","orcid":"0000-0002-8415-4255","position":4,"is_corresponding":false},{"id":855516,"name":"Cynthia S. Indralingam","orcid":null,"position":5,"is_corresponding":false},{"id":571406,"name":"Shengyun Ma","orcid":"0000-0003-3368-9388","position":6,"is_corresponding":false},{"id":242484,"name":"Wendy Huang","orcid":"0000-0001-7425-8280","position":7,"is_corresponding":false},{"id":225253,"name":"John T. Chang","orcid":"0000-0003-0873-6218","position":8,"is_corresponding":false},{"id":236072,"name":"Tiani L. Louis","orcid":"0000-0001-8608-445X","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T01:16:15.380731Z","pmid":"37265401","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}