{"doi":"10.4049/jimmunol.2200578","title":"Cutting Edge: CCR9 Promotes CD8+ T Cell Recruitment to the Brain during Congenital Cytomegalovirus Infection","abstract":"CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8+ T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing chemokine receptor (CCR9) was preferentially expressed in CD8+ T cells localized in the brain postinfection. In the absence of CCR9 or CCL25 (CCR9's ligand) expression, CD8+ T cells failed to migrate to key sites of infection in the brain and protect the host from severe forms of disease. Interestingly, we found that expression of CCR9 on CD8+ T cells was also responsible for spatial temporal positioning of T cells in the brain. Collectively, our data demonstrate that the CMV-infected brain uses a similar mechanism for CD8+ T cell homing as the small intestine.","journal":"The Journal of Immunology","year":2022,"id":284237,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":961506,"name":"Wisler Charles","orcid":"0000-0002-1988-7196","position":1,"is_corresponding":false},{"id":961507,"name":"Katarina E. Cheng","orcid":"0000-0002-0519-6319","position":2,"is_corresponding":false},{"id":961508,"name":"Cybelle Tabilas","orcid":"0000-0001-5846-7269","position":3,"is_corresponding":false},{"id":961509,"name":"Megan Steinhilber","orcid":"0000-0002-0584-7855","position":4,"is_corresponding":false},{"id":961510,"name":"Samantha P. Wesnak","orcid":"0000-0003-3445-7570","position":5,"is_corresponding":false},{"id":728208,"name":"Norah L. Smith","orcid":"0000-0002-7495-7660","position":6,"is_corresponding":false},{"id":292521,"name":"Chris B. Schaffer","orcid":"0000-0002-7800-9596","position":7,"is_corresponding":false},{"id":728209,"name":"Brian D. Rudd","orcid":"0000-0002-9742-8358","position":8,"is_corresponding":false},{"id":251399,"name":"Zachary T. Hilt","orcid":"0000-0001-7084-5613","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T00:29:32.702533Z","pmid":"36469843","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}