{"doi":"10.4049/jimmunol.2200380","title":"FcRγ− NK Cell Induction by Specific Cytomegalovirus and Expansion by Subclinical Viral Infections in Rhesus Macaques","abstract":"\"Adaptive\" NK cells, characterized by FcRγ deficiency and enhanced responsiveness to Ab-bound, virus-infected cells, have been found in certain hCMV-seropositive individuals. Because humans are exposed to numerous microbes and environmental agents, specific relationships between hCMV and FcRγ-deficient NK cells (also known as g-NK cells) have been challenging to define. Here, we show that a subgroup of rhesus CMV (RhCMV)-seropositive macaques possesses FcRγ-deficient NK cells that stably persist and display a phenotype resembling human FcRγ-deficient NK cells. Moreover, these macaque NK cells resembled human FcRγ-deficient NK cells with respect to functional characteristics, including enhanced responsiveness to RhCMV-infected target in an Ab-dependent manner and hyporesponsiveness to tumor and cytokine stimulation. These cells were not detected in specific pathogen-free (SPF) macaques free of RhCMV and six other viruses; however, experimental infection of SPF animals with RhCMV strain UCD59, but not RhCMV strain 68-1 or SIV, led to induction of FcRγ-deficient NK cells. In non-SPF macaques, coinfection by RhCMV with other common viruses was associated with higher frequencies of FcRγ-deficient NK cells. These results support a causal role for specific CMV strain(s) in the induction of FcRγ-deficient NK cells and suggest that coinfection by other viruses further expands this memory-like NK cell pool.","journal":"The Journal of Immunology","year":2023,"id":382033,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":513808,"name":"W. L. William Chang","orcid":"0000-0002-1258-7369","position":1,"is_corresponding":false},{"id":1148644,"name":"Jeannine M. Scott","orcid":null,"position":2,"is_corresponding":false},{"id":1148285,"name":"Suyeon Hong","orcid":"0000-0002-6696-6778","position":3,"is_corresponding":false},{"id":245265,"name":"Tae‐Hyung Lee","orcid":"0009-0009-7292-8805","position":4,"is_corresponding":false},{"id":513809,"name":"Jesse D. Deere","orcid":"0000-0002-2539-0338","position":5,"is_corresponding":false},{"id":1148286,"name":"Peter H. Park","orcid":"0000-0002-7469-0652","position":6,"is_corresponding":false},{"id":513812,"name":"Ellen E. Sparger","orcid":"0000-0001-5244-1500","position":7,"is_corresponding":false},{"id":378910,"name":"Satya Dandekar","orcid":"0000-0002-6346-8028","position":8,"is_corresponding":false},{"id":413411,"name":"Dennis J. Hartigan-O’Connor","orcid":"0000-0003-4822-636X","position":9,"is_corresponding":false},{"id":401501,"name":"Peter A. Barry","orcid":"0000-0002-7982-674X","position":10,"is_corresponding":false},{"id":1148287,"name":"Sungjin Kim","orcid":"0000-0001-7310-1126","position":11,"is_corresponding":false},{"id":672562,"name":"Jaewon Lee","orcid":"0000-0003-3203-2130","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T01:17:17.113710Z","pmid":"37314415","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}