{"doi":"10.4049/jimmunol.2200061","title":"Proteogenomic and V(D)J Analysis of Human Decidual T Cells Highlights Unique Transcriptional Programming and Clonal Distribution","abstract":"Immunological tolerance toward the semiallogeneic fetus is one of many maternal adaptations required for a successful pregnancy. T cells are major players of the adaptive immune system and balance tolerance and protection at the maternal-fetal interface; however, their repertoire and subset programming are still poorly understood. Using emerging single-cell RNA sequencing technologies, we simultaneously obtained transcript, limited protein, and receptor repertoire at the single-cell level, from decidual and matched maternal peripheral human T cells. The decidua maintains a tissue-specific distribution of T cell subsets compared with the periphery. We find that decidual T cells maintain a unique transcriptome programming, characterized by restraint of inflammatory pathways by overexpression of negative regulators (DUSP, TNFAIP3, ZFP36) and expression of PD-1, CTLA-4, TIGIT, and LAG3 in some CD8 clusters. Finally, analyzing TCR clonotypes demonstrated decreased diversity in specific decidual T cell populations. Overall, our data demonstrate the power of multiomics analysis in revealing regulation of fetal-maternal immune coexistence.","journal":"The Journal of Immunology","year":2023,"id":372766,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9453,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":43201,"name":"Rene Welch","orcid":"0000-0001-9861-530X","position":1,"is_corresponding":false},{"id":235477,"name":"Jessica Vázquez","orcid":"0000-0002-8052-3850","position":2,"is_corresponding":false},{"id":439180,"name":"Melina Chavarria","orcid":null,"position":3,"is_corresponding":false},{"id":1133382,"name":"Eryne T. Jenkins","orcid":"0000-0002-2972-2555","position":4,"is_corresponding":false},{"id":439181,"name":"Gladys E. Lopez","orcid":null,"position":5,"is_corresponding":false},{"id":494574,"name":"Chanel T. Tyler","orcid":null,"position":6,"is_corresponding":false},{"id":382827,"name":"Aleksandar K. Stanic","orcid":"0000-0003-1946-6436","position":7,"is_corresponding":false},{"id":298238,"name":"Irene M. Ong","orcid":"0000-0002-9353-6941","position":8,"is_corresponding":false},{"id":306779,"name":"Deborah Chasman","orcid":"0000-0002-7324-0131","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-19T01:15:58.101083Z","pmid":"37195197","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}