{"doi":"10.4049/jimmunol.2101003","title":"Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis","abstract":"Abstract Akt-1 and Akt-2 are the major isoforms of the serine/threonine Akt family that play a key role in controlling immune responses. However, the involvement of Akt-1 and Akt-2 isoforms in antifungal innate immunity is completely unknown. In this study, we show that Akt2−/−, but not Akt1−/−, mice are protected from lethal Candida albicans infection. Loss of Akt-2 facilitates the recruitment of neutrophils and macrophages to the spleen and increases reactive oxygen species expression in these cells. Treating C57BL/6 mice with a specific inhibitor for Akt-2, but not Akt-1, provides protection from lethal C. albicans infection. Our data demonstrate that Akt-2 inhibits antifungal innate immunity by hampering neutrophil and macrophage recruitment to spleens and suppressing oxidative burst, myeloperoxidase activity, and NETosis. We thus describe a novel role for Akt-2 in the regulation of antifungal innate immunity and unveil Akt-2 as a potential target for the treatment of fungal sepsis.","journal":"The Journal of Immunology","year":2022,"id":311519,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9524,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":957361,"name":"Yilei Ma","orcid":null,"position":1,"is_corresponding":false},{"id":52190,"name":"Hui Guo","orcid":"0000-0001-7830-8564","position":2,"is_corresponding":false},{"id":956886,"name":"Na Tang","orcid":"0000-0002-9790-7578","position":3,"is_corresponding":false},{"id":956888,"name":"Song Ouyang","orcid":"0000-0002-4260-3163","position":4,"is_corresponding":false},{"id":1007709,"name":"Patrick Kwadwo Nuro-Gyina","orcid":"0000-0002-2811-1533","position":5,"is_corresponding":false},{"id":672614,"name":"Lijian Tao","orcid":"0000-0003-0816-7588","position":6,"is_corresponding":false},{"id":367098,"name":"Liu Y","orcid":"0000-0002-0994-0109","position":7,"is_corresponding":false},{"id":957363,"name":"Matthew C. O’Brien","orcid":null,"position":8,"is_corresponding":false},{"id":672612,"name":"Wallace Y. Langdon","orcid":"0000-0001-7783-4423","position":9,"is_corresponding":false},{"id":456169,"name":"Jian Zhang","orcid":"0000-0002-9523-5296","position":10,"is_corresponding":false},{"id":1007708,"name":"Ling Huang","orcid":"0000-0001-5584-0419","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T00:33:28.480200Z","pmid":"36130126","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}