{"doi":"10.4049/jimmunol.2100652","title":"Cutting Edge: <scp>l</scp>-Arginine Transfer from Antigen-Presenting Cells Sustains CD4+ T Cell Viability and Proliferation","abstract":"Abstract Metabolomics analyses suggest changes in amino acid abundance, particularly l-arginine (L-ARG), occur in patients with tuberculosis. Immune cells require L-ARG to fuel effector functions following infection. We have previously described an L-ARG synthesis pathway in immune cells; however, its role in APCs has yet to be uncovered. Using a coculture system with mycobacterial-specific CD4+ T cells, we show APC L-ARG synthesis supported T cell viability and proliferation, and activated T cells contained APC-derived L-ARG. We hypothesize that APCs supply L-ARG to support T cell activation under nutrient-limiting conditions. This work expands the current model of APC–T cell interactions and provides insight into the effects of nutrient availability in immune cells.","journal":"The Journal of Immunology","year":2022,"id":277514,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9521,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":706474,"name":"Stephanie Schmidt","orcid":"0009-0002-5451-3293","position":1,"is_corresponding":false},{"id":651134,"name":"Shannon Lange","orcid":"0000-0003-3907-6072","position":2,"is_corresponding":false},{"id":706473,"name":"Melanie C. McKell","orcid":"0000-0003-2502-7421","position":3,"is_corresponding":false},{"id":707082,"name":"Michelle C. Robillard","orcid":null,"position":4,"is_corresponding":false},{"id":705208,"name":"Junfang Zhao","orcid":"0000-0003-1777-5665","position":5,"is_corresponding":false},{"id":481512,"name":"Wendy D. Haffey","orcid":"0000-0001-7957-280X","position":6,"is_corresponding":false},{"id":455025,"name":"Michael A. Wyder","orcid":"0000-0001-7355-2250","position":7,"is_corresponding":false},{"id":87808,"name":"Kenneth D. Greis","orcid":"0000-0002-5316-3351","position":8,"is_corresponding":false},{"id":526807,"name":"Kenneth D.R. Setchell","orcid":"0000-0001-9147-0136","position":9,"is_corresponding":false},{"id":640694,"name":"Joseph E. Qualls","orcid":"0000-0002-0113-2166","position":10,"is_corresponding":false},{"id":688196,"name":"Rebecca R. Crowther","orcid":"0000-0003-3190-9498","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T00:28:39.226969Z","pmid":"35101895","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}