{"doi":"10.4049/jimmunol.2100149","title":"Cutting Edge: Neutralizing Public Antibody Responses Are an Ancient Form of Defense Conserved in Fish and Mammals","abstract":"The repertoire of Abs is generated by genomic rearrangements during B cell differentiation. Although V(D)J rearrangements lead to repertoires mostly different between individuals, recent studies have shown that they contain a substantial fraction of overrepresented and shared \"public\" clones. We previously reported a strong public IgHμ clonotypic response against the rhabdovirus viral hemorrhagic septicemia virus in a teleost fish. In this study, we identified an IgL chain associated with this public response that allowed us to characterize its functionality. We show that this public Ab response has a potent neutralizing capacity that is typically associated with host protection during rhabdovirus infections. We also demonstrate that the public response is not restricted to a particular trout isogenic line but expressed in multiple genetic backgrounds and may be used as a marker of successful vaccination. Our work reveals that public B cell responses producing generic Abs constitute a mechanism of protection against infection conserved across vertebrates.","journal":"The Journal of Immunology","year":2021,"id":196162,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":768199,"name":"Sofie Navelsaker","orcid":"0000-0002-8221-2036","position":1,"is_corresponding":false},{"id":768200,"name":"Bertrand Collet","orcid":"0000-0003-2795-2653","position":2,"is_corresponding":false},{"id":768201,"name":"Luc Jouneau","orcid":"0000-0002-5094-7302","position":3,"is_corresponding":false},{"id":768202,"name":"Pascal Bochet","orcid":"0000-0002-0310-3166","position":4,"is_corresponding":false},{"id":768709,"name":"Edwige Quillet","orcid":null,"position":5,"is_corresponding":false},{"id":768203,"name":"Øystein Evensen","orcid":"0000-0003-3538-3657","position":6,"is_corresponding":false},{"id":256113,"name":"J. Oriol Sunyer","orcid":"0000-0001-5093-2429","position":7,"is_corresponding":false},{"id":768204,"name":"Simon Fillatreau","orcid":"0000-0002-7730-9917","position":8,"is_corresponding":false},{"id":632315,"name":"Pierre Bruhns","orcid":"0000-0002-4709-8936","position":9,"is_corresponding":false},{"id":768205,"name":"Thierry Rose","orcid":"0000-0001-8863-0207","position":10,"is_corresponding":false},{"id":632310,"name":"François Huetz","orcid":"0000-0001-8704-1881","position":11,"is_corresponding":false},{"id":768206,"name":"Pierre Boudinot","orcid":"0000-0002-7490-9677","position":12,"is_corresponding":false},{"id":595898,"name":"Rosario Castro","orcid":"0000-0003-0928-6984","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-18T23:50:11.609550Z","pmid":"34233911","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}