{"doi":"10.4049/jimmunol.2100017","title":"MicroRNA-10a Negatively Regulates CD4+ T Cell IL-10 Production through Suppression of Blimp1","abstract":"Abstract An uncontrolled CD4+ T cell response is a critical hallmark of autoimmune diseases. IL-10, which can be produced by both effector and regulatory CD4+ T cells, plays an essential role in the inhibition of autoimmunity. MicroRNAs are key molecules involved in regulating immune responses. However, how miR-10a regulates CD4+ T cell function in the pathogenesis of intestinal immune responses is not fully understood. In this study, we show that the mice with deficient miR-10a in CD4+ T cells were more resistant to intestinal inflammation upon inflammatory insult. miR-10a–deficient CD4+CD45Rbhi T cells were less colitogenic in Rag−/− mice, in which CD4+ T cell production of IL-10 was increased. miR-10a–deficient CD4+ T cells expressed a higher expression of IL-10 in vitro. Blocking the IL-10/IL-10R pathway in vivo aggravated colitis induced by miR-10a–deficient CD4+CD45Rbhi T cells. Mechanically, miR-10a suppressed CD4+ T cell production of IL-10 through targeting Prdm1, which encodes Blimp1. We further show that that CD4+ T cells lacking Blimp1 produced lower levels of IL-10 and induced more severe colitis in Rag−/− mice. These data thus establish the role of miR-10a in the inhibition of IL-10 production in CD4+ T cells to regulate intestinal homeostasis.","journal":"The Journal of Immunology","year":2021,"id":191104,"datarank":0.6356920871352465,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.2398334876929576,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.2398334876929576,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":11,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9495,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":756048,"name":"Liang Chen","orcid":"0000-0002-8098-2547","position":1,"is_corresponding":false},{"id":107268,"name":"Leiqi Xu","orcid":"0000-0001-9737-2289","position":2,"is_corresponding":false},{"id":107267,"name":"Anthony J. Bilotta","orcid":null,"position":3,"is_corresponding":false},{"id":107274,"name":"Suxia Yao","orcid":null,"position":4,"is_corresponding":false},{"id":107278,"name":"Zhanju Liu","orcid":"0000-0002-0326-543X","position":5,"is_corresponding":false},{"id":107279,"name":"Yingzi Cong","orcid":"0000-0003-4167-7395","position":6,"is_corresponding":false},{"id":107264,"name":"Wenjing Yang","orcid":"0000-0003-1541-1892","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:49:31.121780Z","pmid":"34301843","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}