{"doi":"10.4049/jimmunol.208.supp.65.13","title":"Robust and prototypical immune responses towards COVID-19 BNT162b2 vaccines in Indigenous people","abstract":"Abstract SARS-CoV-2 has led to >270 million infections and >5 million deaths globally. Indigenous people are disproportionately affected by infectious diseases, therefore also more susceptible to the COVID-19 pandemic. There are an estimated 476 million indigenous people globally, including an estimated 798,365 Aboriginal and Torres Strait Islander in Australia. With the high vulnerability to COVID-19, this knowledge is urgently needed to better protect indigenous populations. We evaluated a breadth of immune responses in indigenous (n=57) and non-indigenous (n=49) individuals after COVID-19 vaccination. We tested RBD antibodies, spike/RBD-probe-specific B cells, peptide stimulations with activation-induced marker (AIM) assay and intracellular cytokine staining. We found 22% and 34% seroconversion rates after 1st dose of BNT162b2 vaccine for Indigenous and non-indigenous individuals, respectively, which increased to 100% at 1-mth after 2nd dose for both groups. RBD-specific IgG levels in indigenous individuals at 1-mth after 2nd dose positively correlated with their body mass index. At 1-mth after the 2nd COVID-19 vaccination, CD4+ and CD8+ T cell responses via AIM expression and IFN-γ+ TNF+ production was comparable between indigenous and non-indigenous individuals. We are also going to assess the longevity of antibodies and T cells. Therefore, COVID-19 vaccination induced similar immune responses in indigenous and non-indigenous individuals.","journal":"The Journal of Immunology","year":2022,"id":305209,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9494,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":883326,"name":"Łukasz Kedzierski","orcid":"0000-0003-0203-1057","position":1,"is_corresponding":false},{"id":883325,"name":"Brendon Y. Chua","orcid":"0000-0001-5654-1293","position":2,"is_corresponding":false},{"id":108825,"name":"Adam K. Wheatley","orcid":"0000-0002-5593-9387","position":3,"is_corresponding":false},{"id":618936,"name":"Louise C. Rowntree","orcid":"0000-0002-0649-5089","position":4,"is_corresponding":false},{"id":883332,"name":"Lilith F. Allen","orcid":"0000-0002-4197-2573","position":5,"is_corresponding":false},{"id":618934,"name":"Jan Petersen","orcid":"0000-0002-2045-6342","position":6,"is_corresponding":false},{"id":999136,"name":"Priyanka Chaurasia","orcid":"0000-0002-3755-159X","position":7,"is_corresponding":false},{"id":496184,"name":"Robert C. Mettelman","orcid":"0000-0002-3527-5616","position":8,"is_corresponding":false},{"id":728702,"name":"Adrian Miller","orcid":"0000-0001-9735-6609","position":9,"is_corresponding":false},{"id":225737,"name":"Paul G. Thomas","orcid":"0000-0001-7955-0256","position":10,"is_corresponding":false},{"id":256186,"name":"Jamie Rossjohn","orcid":"0000-0002-2020-7522","position":11,"is_corresponding":false},{"id":265999,"name":"Kanta Subbarao","orcid":"0000-0003-1713-3056","position":12,"is_corresponding":false},{"id":108826,"name":"Stephen J. Kent","orcid":"0000-0002-8539-4891","position":13,"is_corresponding":false},{"id":236365,"name":"Jane Nelson","orcid":"0000-0003-1690-746X","position":14,"is_corresponding":false},{"id":236374,"name":"Jane Davies","orcid":"0000-0002-3843-837X","position":15,"is_corresponding":false},{"id":104914,"name":"Thi H. O. Nguyen","orcid":"0000-0002-9294-7693","position":16,"is_corresponding":false},{"id":104934,"name":"Katherine Kedzierska","orcid":"0000-0001-6141-335X","position":17,"is_corresponding":false},{"id":632589,"name":"Wuji Zhang","orcid":"0000-0001-7460-4956","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T00:32:41.290883Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}