{"doi":"10.4049/jimmunol.2001432","title":"Local Sustained Delivery of Anti–IL-17A Antibodies Limits Inflammatory Bone Loss in Murine Experimental Periodontitis","abstract":"Periodontal disease (PD) is a chronic destructive inflammatory disease of the tooth-supporting structures that leads to tooth loss at its advanced stages. Although the disease is initiated by a complex organization of oral microorganisms in the form of a plaque biofilm, it is the uncontrolled immune response to periodontal pathogens that fuels periodontal tissue destruction. IL-17A has been identified as a key cytokine in the pathogenesis of PD. Despite its well documented role in host defense against invading pathogens at oral barrier sites, IL-17A-mediated signaling can also lead to a detrimental inflammatory response, causing periodontal bone destruction. In this study, we developed a local sustained delivery system that restrains IL-17A hyperactivity in periodontal tissues by incorporating neutralizing anti-IL-17A Abs in poly(lactic-coglycolic) acid microparticles (MP). This formulation allowed for controlled release of anti-IL-17A in the periodontium of mice with ligature-induced PD. Local delivery of anti-IL-17A MP after murine PD induction inhibited alveolar bone loss and osteoclastic activity. The anti-IL-17A MP formulation also decreased expression of IL-6, an IL-17A target gene known to induce bone resorption in periodontal tissues. This study demonstrates proof of concept that local and sustained release of IL-17A Abs constitutes a promising therapeutic strategy for PD and may be applicable to other osteolytic bone diseases mediated by IL-17A-driven inflammation.","journal":"The Journal of Immunology","year":2021,"id":166702,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":692592,"name":"K. L. M. Maltos","orcid":"0000-0001-7013-7043","position":1,"is_corresponding":false},{"id":692593,"name":"Mostafa Shehabeldin","orcid":"0000-0002-2122-4105","position":2,"is_corresponding":false},{"id":692594,"name":"Laura L. Thomas","orcid":"0000-0002-9729-5081","position":3,"is_corresponding":false},{"id":692595,"name":"Zhe Zhuang","orcid":"0000-0002-8049-1166","position":4,"is_corresponding":false},{"id":692596,"name":"Sayuri Yoshizawa","orcid":"0000-0002-0976-8521","position":5,"is_corresponding":false},{"id":499185,"name":"Konstantinos Verdelis","orcid":"0000-0002-1632-8305","position":6,"is_corresponding":false},{"id":37710,"name":"Sarah L. Gaffen","orcid":"0000-0001-8511-2041","position":7,"is_corresponding":false},{"id":692597,"name":"Gustavo Pompermaier Garlet","orcid":"0000-0002-5071-8382","position":8,"is_corresponding":false},{"id":417616,"name":"Steven R. Little","orcid":"0000-0002-7000-3931","position":9,"is_corresponding":false},{"id":692598,"name":"Charles Sfeir","orcid":"0000-0003-3163-3292","position":10,"is_corresponding":false},{"id":693247,"name":"Cinthia M. F. Pacheco","orcid":null,"position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-18T23:45:49.644768Z","pmid":"33952619","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}