{"doi":"10.4049/jimmunol.2001279","title":"The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma","abstract":"Abstract MRL/lpr mice typically succumb to immune complex–mediated nephritis within the first year of life. However, MRL/lpr mice that only secrete IgM Abs because of activation-induced deaminase deficiency (AID–/–MRL/lpr mice) experienced a dramatic increase in survival. Further crossing of these mice to those incapable of making secretory IgM (μS mice) generated mice lacking any secreted Abs but with normal B cell receptors. Both strains revealed no kidney pathology, yet Ab-deficient mice still experienced high mortality. In this article, we report Ab-deficient MRL/lpr mice progressed to high-grade T cell lymphoma that can be reversed with injection of autoreactive IgM Abs or following adoptive transfer of IgM-secreting MRL/lpr B cells. Anti-nuclear Abs, particularly anti-dsDNA IgM Abs, exhibited tumor-killing activities against a murine T cell lymphoma cell line. Passive transfers of autoreactive IgM Abs into p53-deficient mice increased survival by delaying onset of T cell lymphoma. The lymphoma originated from a double-negative aberrant T cell population seen in MRL/lpr mice and most closely resembled human anaplastic large cell lymphoma. Combined, these results strongly implicate autoreactive IgM Abs in protection against T cell lymphoma.","journal":"The Journal of Immunology","year":2021,"id":223831,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9471,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":470560,"name":"Ming‐Lang Zhao","orcid":null,"position":1,"is_corresponding":false},{"id":825618,"name":"Luis Ramos","orcid":"0000-0002-8483-0778","position":2,"is_corresponding":false},{"id":729849,"name":"Katarzyna Dobaczewska","orcid":"0000-0002-6377-018X","position":3,"is_corresponding":false},{"id":825999,"name":"Ronald Herbert","orcid":null,"position":4,"is_corresponding":false},{"id":501481,"name":"Kristen Hobbie","orcid":"0000-0002-9933-4080","position":5,"is_corresponding":false},{"id":273867,"name":"Zbigniew Mikulski","orcid":"0000-0002-1918-9216","position":6,"is_corresponding":false},{"id":469215,"name":"Laurent Verkoczy","orcid":"0000-0001-7497-6645","position":7,"is_corresponding":false},{"id":546747,"name":"Marilyn Diaz","orcid":"0000-0002-3046-2746","position":8,"is_corresponding":false},{"id":547428,"name":"Chuancang Jiang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-18T23:54:14.760456Z","pmid":"33883189","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}