{"doi":"10.4049/jimmunol.2000583","title":"A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection","abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for millions of infections and hundreds of thousands of deaths globally. There are no widely available licensed therapeutics against SARS-CoV-2, highlighting an urgent need for effective interventions. The virus enters host cells through binding of a receptor-binding domain within its trimeric spike glycoprotein to human angiotensin-converting enzyme 2. In this article, we describe the generation and characterization of a panel of murine mAbs directed against the receptor-binding domain. One mAb, 2B04, neutralized wild-type SARS-CoV-2 in vitro with remarkable potency (half-maximal inhibitory concentration of <2 ng/ml). In a murine model of SARS-CoV-2 infection, 2B04 protected challenged animals from weight loss, reduced lung viral load, and blocked systemic dissemination. Thus, 2B04 is a promising candidate for an effective antiviral that can be used to prevent SARS-CoV-2 infection.","journal":"The Journal of Immunology","year":2020,"id":49892,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":223,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9502,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":225532,"name":"Jackson S. Turner","orcid":"0000-0002-4396-6265","position":1,"is_corresponding":false},{"id":106498,"name":"James Brett Case","orcid":"0000-0001-7331-5511","position":2,"is_corresponding":false},{"id":227333,"name":"Haiyan Zhao","orcid":"0000-0001-5123-5537","position":3,"is_corresponding":false},{"id":225533,"name":"Aaron J. Schmitz","orcid":"0000-0002-8077-6751","position":4,"is_corresponding":false},{"id":242710,"name":"Julian Q. Zhou","orcid":"0000-0001-9602-2092","position":5,"is_corresponding":false},{"id":106500,"name":"Rita E. Chen","orcid":"0000-0002-5100-7750","position":6,"is_corresponding":false},{"id":55451,"name":"Tingting Lei","orcid":"0000-0002-8592-4178","position":7,"is_corresponding":false},{"id":244128,"name":"Amena A. Rizk","orcid":null,"position":8,"is_corresponding":false},{"id":242711,"name":"Katherine M. McIntire","orcid":"0000-0002-6262-4260","position":9,"is_corresponding":false},{"id":106514,"name":"Emma S. Winkler","orcid":"0000-0001-8510-1385","position":10,"is_corresponding":false},{"id":106515,"name":"Julie M. Fox","orcid":"0000-0003-0567-738X","position":11,"is_corresponding":false},{"id":106513,"name":"Natasha M. Kafai","orcid":"0000-0002-3115-3400","position":12,"is_corresponding":false},{"id":106528,"name":"Larissa B. Thackray","orcid":"0000-0002-9380-6569","position":13,"is_corresponding":false},{"id":106512,"name":"Ahmed O. Hassan","orcid":"0000-0002-9638-1260","position":14,"is_corresponding":false},{"id":104911,"name":"Fatima Amanat","orcid":"0000-0002-8029-8227","position":15,"is_corresponding":false},{"id":103779,"name":"Florian Krammer","orcid":"0000-0003-4121-776X","position":16,"is_corresponding":false},{"id":51382,"name":"Corey T. Watson","orcid":"0000-0001-7248-8787","position":17,"is_corresponding":false},{"id":6493,"name":"Steven H. Kleinstein","orcid":"0000-0003-4957-1544","position":18,"is_corresponding":false},{"id":225534,"name":"Daved H. Fremont","orcid":"0000-0002-8544-2689","position":19,"is_corresponding":false},{"id":106529,"name":"Michael Diamond","orcid":"0000-0002-8791-3165","position":20,"is_corresponding":false},{"id":225537,"name":"Ali H. Ellebedy","orcid":"0000-0002-6129-2532","position":21,"is_corresponding":false},{"id":225531,"name":"Wafaa B. Alsoussi","orcid":"0000-0002-5805-4461","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-18T20:37:28.027635Z","pmid":"32591393","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}