{"doi":"10.4049/jimmunol.2000280","title":"IL-23 Promotes a Coordinated B Cell Germinal Center Program for Class-Switch Recombination to IgG2b in BXD2 Mice","abstract":"Abstract IL-23 promotes autoimmune disease, including Th17 CD4 T cell development and autoantibody production. In this study, we show that a deficiency of the p19 component of IL-23 in the autoimmune BXD2 (BXD2-p19−/−) mouse leads to a shift of the follicular T helper cell program from follicular T helper (Tfh)–IL-17 to Tfh–IFN-γ. Although the germinal center (GC) size and the number of GC B cells remained the same, BXD2-p19−/− mice exhibited a lower class-switch recombination (CSR) in the GC B cells, leading to lower serum levels of IgG2b. Single-cell transcriptomics analysis of GC B cells revealed that whereas Ifngr1, Il21r, and Il4r genes exhibited a synchronized expression pattern with Cxcr5 and plasma cell program genes, Il17ra exhibited a synchronized expression pattern with Cxcr4 and GC program genes. Downregulation of Ighg2b in BXD2-p19−/− GC B cells was associated with decreased expression of CSR-related novel base excision repair genes that were otherwise predominantly expressed by Il17ra+ GC B cells in BXD2 mice. Together, these results suggest that although IL-23 is dispensable for GC formation, it is essential to promote a population of Tfh–IL-17 cells. IL-23 acts indirectly on Il17ra+ GC B cells to facilitate CSR-related base excision repair genes during the dark zone phase of GC B cell development.","journal":"The Journal of Immunology","year":2020,"id":71040,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":249178,"name":"Min Gao","orcid":"0000-0002-5592-9349","position":1,"is_corresponding":false},{"id":375922,"name":"Qi Wu","orcid":"0000-0002-7626-6089","position":2,"is_corresponding":false},{"id":377499,"name":"PingAr Yang","orcid":null,"position":3,"is_corresponding":false},{"id":361443,"name":"Shanrun Liu","orcid":"0000-0002-7201-4212","position":4,"is_corresponding":false},{"id":281382,"name":"Hao Li","orcid":"0000-0002-2171-8826","position":5,"is_corresponding":false},{"id":375923,"name":"Peter D. Burrows","orcid":"0000-0002-5752-5647","position":6,"is_corresponding":false},{"id":377500,"name":"Daniel Cua","orcid":null,"position":7,"is_corresponding":false},{"id":14606,"name":"Jake Y. Chen","orcid":"0000-0001-8829-7504","position":8,"is_corresponding":false},{"id":375924,"name":"Hui‐Chen Hsu","orcid":"0000-0002-0317-5725","position":9,"is_corresponding":false},{"id":375925,"name":"John D. Mountz","orcid":"0000-0001-9061-3158","position":10,"is_corresponding":false},{"id":375921,"name":"Huixian Hong","orcid":"0000-0001-7283-8775","position":0,"is_corresponding":true}],"reference_count":79,"raw_metadata":null,"created_at":"2026-07-18T21:43:57.004133Z","pmid":"32554431","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}