{"doi":"10.4049/jimmunol.1901484","title":"T Cell–Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation","abstract":"Abstract Aging-related chronic inflammation is a risk factor for many human disorders through incompletely understood mechanisms. Aged mice deficient in microRNA (miRNA/miR)-146a succumb to life-shortening chronic inflammation. In this study, we report that miR-155 in T cells contributes to shortened lifespan of miR-146a−/− mice. Using single-cell RNA sequencing and flow cytometry, we found that miR-155 promotes the activation of effector T cell populations, including T follicular helper cells, and increases germinal center B cells and autoantibodies in mice aged over 15 months. Mechanistically, aerobic glycolysis genes are elevated in T cells during aging, and upon deletion of miR-146a, in a T cell miR-155-dependent manner. Finally, skewing T cell metabolism toward aerobic glycolysis by deleting mitochondrial pyruvate carrier recapitulates age-dependent T cell phenotypes observed in miR-146a−/− mice, revealing the sufficiency of metabolic reprogramming to influence immune cell functions during aging. Altogether, these data indicate that T cell–specific miRNAs play pivotal roles in regulating lifespan through their influences on inflammaging.","journal":"The Journal of Immunology","year":2020,"id":75325,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9519,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":352019,"name":"Andrew G. Ramstead","orcid":null,"position":1,"is_corresponding":false},{"id":350132,"name":"Soh-Hyun Lee","orcid":"0000-0001-6620-8961","position":2,"is_corresponding":false},{"id":393187,"name":"Morgan C. Nelson","orcid":"0000-0001-9812-499X","position":3,"is_corresponding":false},{"id":350133,"name":"Kaylyn M. Bauer","orcid":"0000-0002-5498-9083","position":4,"is_corresponding":false},{"id":352020,"name":"Jared Wallace","orcid":null,"position":5,"is_corresponding":false},{"id":16275,"name":"Ruozhen Hu","orcid":null,"position":6,"is_corresponding":false},{"id":253554,"name":"June L. Round","orcid":"0000-0002-7158-9874","position":7,"is_corresponding":false},{"id":232415,"name":"Jared Rutter","orcid":"0000-0002-2710-9765","position":8,"is_corresponding":false},{"id":393188,"name":"Micah J. Drummond","orcid":"0000-0001-5961-8890","position":9,"is_corresponding":false},{"id":393189,"name":"Dinesh S. Rao","orcid":"0000-0002-0794-9337","position":10,"is_corresponding":false},{"id":289854,"name":"Ryan M. O’Connell","orcid":"0000-0003-0860-1401","position":11,"is_corresponding":false},{"id":289851,"name":"H. Atakan Ekiz","orcid":"0000-0001-7718-6841","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-18T21:46:33.313355Z","pmid":"32161096","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}