{"doi":"10.4049/jimmunol.1900532","title":"IL-10 Dampens an IL-17–Mediated Periodontitis-Associated Inflammatory Network","abstract":"Abstract Emerging evidence suggests comprehensive immune profiling represents a highly promising, yet insufficiently tapped approach to identify potentially prognostic signatures for periodontitis. In this report, we agnostically identified a periodontitis-associated inflammatory expression network with multiple biomarkers identified within gingival crevicular fluid samples from study participants by applying principal component analysis. We identified an IL-17–dominated trait that is associated with periodontal disease and is inversely modified by the level of IL-10. IL-10 mitigated chemokine CXCL5 and CXCL1 expressions in IL-17–stimulated peripheral blood monocytic cells and peripheral blood monocytic cell–derived macrophages. Il10-deficient mice presented more bone loss, which was associated with more Il17 and IL-17–mediated chemokine and cytokine expression at the transcriptional levels in comparison with control wild-type mice in both the Porphyromonas gingivalis–induced experimental murine periodontitis and ligature-induced alveolar bone-loss models. The dampening effect of IL-10 on the excessive signaling of IL-17 appeared to be mediated by innate immune cells populations rather than by gingival epithelial cells, which are the major cell target for IL-17 signaling. Additionally, elevated IL-17 response in Il10-deficient mice specifically elicited an M1-skewing macrophage phenotype in the gingiva that was associated with the advanced bone loss in the ligature model. In summary, IL-17 dominated an inflammatory network characteristic of periodontitis, and IL-10 dampens this excessive IL-17–mediated periodontitis trait.","journal":"The Journal of Immunology","year":2020,"id":56295,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":86,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":293708,"name":"Mustafa Girnary","orcid":null,"position":1,"is_corresponding":false},{"id":292340,"name":"Lufei Wang","orcid":"0000-0003-4691-2665","position":2,"is_corresponding":false},{"id":109657,"name":"Yizu Jiao","orcid":null,"position":3,"is_corresponding":false},{"id":292341,"name":"Erliang Zeng","orcid":"0000-0002-2891-6497","position":4,"is_corresponding":false},{"id":293709,"name":"Kyle Mercer","orcid":null,"position":5,"is_corresponding":false},{"id":293710,"name":"Jinmei Zhang","orcid":null,"position":6,"is_corresponding":false},{"id":292342,"name":"Julie T. Marchesan","orcid":"0000-0003-0610-3193","position":7,"is_corresponding":false},{"id":292343,"name":"Ning Yu","orcid":"0000-0002-3046-4338","position":8,"is_corresponding":false},{"id":292344,"name":"Kevin Moss","orcid":"0000-0003-2332-1774","position":9,"is_corresponding":false},{"id":109672,"name":"Yu L. Lei","orcid":"0000-0002-9868-9824","position":10,"is_corresponding":false},{"id":292345,"name":"Steven Offenbacher","orcid":"0000-0002-0727-9441","position":11,"is_corresponding":false},{"id":292346,"name":"Shaoping Zhang","orcid":"0000-0003-3004-4023","position":12,"is_corresponding":false},{"id":292339,"name":"Lu Sun","orcid":"0000-0002-6592-1156","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-18T21:05:49.581291Z","pmid":"32169848","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}