{"doi":"10.4049/jimmunol.186.supp.109.14","title":"VDUP1 inhibits NF-κB activity via association with HDAC1 and HDAC3 (109.14)","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>NF-κB subunits are important regulators of apoptosis or cellular responses triggered by tumor necrosis factor TNF-α. Termination of nuclear NF-κB action is regulated by histone deacetylase (HDAC) corepressor proteins. However, the molecular mechanism that leads to the termination is not fully understood. Here, we examined the functions of VDUP1, a negative regulator of thioredoxin, in TNF-α-mediated NF-κB activation. VDUP1 level was markedly reduced by TNF-α stimulation, concomitant with elevated NF-κB activation. Furthermore, Enforced VDUP1 overexpression suppressed strongly the increased NF-κB activity. In addition, the overexpresion of VDUP1 resulted in the robust suppression of TNF-α-activated NF-κB activity via association with HDAC1 or HDAC3. Collectively, we identified VDUP1 as a new component of the corepressors by demonstrating its ability to repress NF-κB activation, during which HDAC1 and HDAC3 interact with NF-κB p65 to suppress the NF-κB activity</jats:p>","journal":"The Journal of Immunology","year":2011,"id":14364,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":113793,"name":"Hyun-Woo Suh","orcid":null,"position":1,"is_corresponding":false},{"id":113794,"name":"Haiyoung Jung","orcid":null,"position":2,"is_corresponding":false},{"id":113795,"name":"Suk-Ran Yoon","orcid":null,"position":3,"is_corresponding":false},{"id":113796,"name":"Inpyo Choi","orcid":null,"position":4,"is_corresponding":false},{"id":97047,"name":"Young-Jun Park","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24259432","pmcid":null,"openalex_id":"https://openalex.org/W4313349731","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.37205274,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://academic.oup.com/jimmunol/article/186/1_Supplement/109.14/7982992","host_type":"publisher"},{"url":"https://doi.org/10.4049/jimmunol.186.supp.109.14","host_type":"journal"}],"fields_of_study":["Genomics, phytochemicals, and oxidative stress","Sirtuins and Resveratrol in Medicine","Histone Deacetylase Inhibitors Research","Medicine","Biology","Chemistry"],"mesh_terms":[],"keywords":["HDAC3","HDAC1","Corepressor","NF-κB","Chemistry","Tumor necrosis factor alpha","Cell biology","Transcription factor","Apoptosis","Cancer research","Histone","Histone deacetylase","Biology","Repressor","Biochemistry","Endocrinology","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T09:05:29.243283Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}