{"doi":"10.4049/jimmunol.1801349","title":"Cutting Edge: T Cell–Dependent Plasmablasts Form in the Absence of Single Differentiated CD4+ T Cell Subsets","abstract":"Abstract\n The T follicular helper (Tfh) cell subset of CD4+ Th cells promotes affinity maturation by B cells in germinal centers. The contribution of other Th cell subsets to B cell responses has not been fully explored in vivo. We addressed this issue by analyzing the T cell–dependent B cell response to the protein Ag PE in mice lacking specific Th cell subsets. As expected, PE-specific germinal center B cell production required Tfh cells. However, Tfh, Th1, or Th17 cell–deficient mice produced as many PE-specific, isotype-switched plasmablasts as wild-type mice. This response depended on Th cell expression of CD154 and Ag presentation by B cells. These results indicate that many Th cell subsets can promote plasmablast formation by providing CD40 signals to naive B cells.","journal":"The Journal of Immunology","year":2019,"id":594321,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":318063,"name":"Marc K. Jenkins","orcid":"0000-0001-8009-7655","position":1,"is_corresponding":false},{"id":965888,"name":"Jessica Kotov","orcid":"0000-0002-1205-5178","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cutting Edge: T Cell–Dependent Plasmablasts Form in the Absence of Single Differentiated CD4+ T Cell Subsets","abstract":"Abstract\n The T follicular helper (Tfh) cell subset of CD4+ Th cells promotes affinity maturation by B cells in germinal centers. The contribution of other Th cell subsets to B cell responses has not been fully explored in vivo. We addressed this issue by analyzing the T cell–dependent B cell response to the protein Ag PE in mice lacking specific Th cell subsets. As expected, PE-specific germinal center B cell production required Tfh cells. However, Tfh, Th1, or Th17 cell–deficient mice produced as many PE-specific, isotype-switched plasmablasts as wild-type mice. This response depended on Th cell expression of CD154 and Ag presentation by B cells. These results indicate that many Th cell subsets can promote plasmablast formation by providing CD40 signals to naive B cells.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30552165","pmcid":"PMC6324993","openalex_id":"https://openalex.org/W2903620476","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI027998","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI039614","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R37 AI027998","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"T32 AI007313","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"F31 AI133716","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI103760","title":null}],"total_grants":6,"fwci":0.7616,"citation_percentile":0.70243128,"influential_citations":0,"citation_trend":[{"year":2019,"count":4},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":5},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"bronze","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://www.jimmunol.org/content/jimmunol/202/2/401.full.pdf","host_type":"journal"},{"url":"https://www.jimmunol.org/content/jimmunol/202/2/401.full.pdf","host_type":"BRONZE"},{"url":"https://www.jimmunol.org/content/jimmunol/202/2/401.full.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/jimmunol/article-pdf/202/2/401/61871985/ji1801349.pdf","host_type":"publisher"},{"url":"https://doi.org/10.4049/jimmunol.1801349","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30552165","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6324993","host_type":"repository"}],"fields_of_study":["T-cell and B-cell Immunology","Immune Cell Function and Interaction","Immunotherapy and Immune Responses","Biology"],"mesh_terms":["Animals","Antibody Affinity","Antibody-Producing Cells","Cell Communication","Cell Differentiation","Cells, Cultured","Female","Male","Mice, Inbred C57BL","Mice, Transgenic","Plasma Cells","Signal Transduction","CD4-Positive T-Lymphocytes","T-Lymphocyte Subsets","Immunoglobulin Class Switching","Antigen Presentation","Germinal Center","CD40 Antigens","CD40 Ligand","Mice"],"keywords":["Enhanced Data Rates for GSM Evolution","Cell","Cell biology","Chemistry","Biology","Computer science","Biochemistry","Artificial intelligence"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T14:16:59.841943Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}