{"doi":"10.4049/jimmunol.177.9.6025","title":"Enhanced IgA Class Switching in Marginal Zone and B1 B Cells Relative to Follicular/B2 B Cells","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal cavity respond preferentially to T cell-independent Ags compared with follicular (FO)/B2 B cells. Despite the differential responses of B cell subsets to various stimuli, and despite the need for multiple stimuli to induce IgA class switching, the relative contribution of B cell subpopulations to IgA production is unknown. By culturing purified B cell populations, we find that MZ and peritoneal B1 cells switch more readily to IgA than do splenic FO or peritoneal B2 cells in BLyS/LPS/TGF-β. Addition of IL-4, IL-5, and anti-IgD dextran to the cultures enhances IgA switching in FO/B2 and MZ B cells to a similar frequency, but this treatment suppresses IgA class switching in B1 cells. Thus, IgA switching differs among purified B cell subsets, suggesting that individual B cell populations could contribute differentially to IgA expression in vivo, depending on available stimuli.</jats:p>","journal":"The Journal of Immunology","year":2006,"id":620436,"datarank":0.6749714505495399,"base_score":4.499809670330265,"endowment":4.499809670330265,"self_citation_contribution":0.6749714505495399,"citation_network_contribution":0.0,"self_endowment_contribution":0.6749714505495399,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":89,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1601672,"name":"Janet Stavnezer","orcid":null,"position":1,"is_corresponding":false},{"id":1601670,"name":"Denise A Kaminski","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Enhanced IgA Class Switching in Marginal Zone and B1 B Cells Relative to Follicular/B2 B Cells","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Mouse splenic marginal zone (MZ) B cells and B1 B cells enriched in the peritoneal cavity respond preferentially to T cell-independent Ags compared with follicular (FO)/B2 B cells. Despite the differential responses of B cell subsets to various stimuli, and despite the need for multiple stimuli to induce IgA class switching, the relative contribution of B cell subpopulations to IgA production is unknown. By culturing purified B cell populations, we find that MZ and peritoneal B1 cells switch more readily to IgA than do splenic FO or peritoneal B2 cells in BLyS/LPS/TGF-β. Addition of IL-4, IL-5, and anti-IgD dextran to the cultures enhances IgA switching in FO/B2 and MZ B cells to a similar frequency, but this treatment suppresses IgA class switching in B1 cells. Thus, IgA switching differs among purified B cell subsets, suggesting that individual B cell populations could contribute differentially to IgA expression in vivo, depending on available stimuli.</jats:p>","is_dataset_classified":null,"base_score":4.499809670330265,"endowment":4.499809670330265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17056527","pmcid":null,"openalex_id":"https://openalex.org/W2127605373","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"F32 AI 056806","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R21 AI 062738","title":null}],"total_grants":2,"fwci":1.6189,"citation_percentile":0.83765226,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":7},{"year":2014,"count":5},{"year":2015,"count":4},{"year":2016,"count":6},{"year":2017,"count":5},{"year":2018,"count":6},{"year":2019,"count":3},{"year":2020,"count":6},{"year":2021,"count":3},{"year":2022,"count":4},{"year":2024,"count":5},{"year":2025,"count":2}],"oa_status":"bronze","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://journals.aai.org/jimmunol/article-pdf/177/9/6025/1229917/zim02106006025.pdf","host_type":"journal"},{"url":"https://journals.aai.org/jimmunol/article-pdf/177/9/6025/1229917/zim02106006025.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/jimmunol/article-pdf/177/9/6025/62649563/zim02106006025.pdf","host_type":"publisher"},{"url":"https://doi.org/10.4049/jimmunol.177.9.6025","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17056527","host_type":"repository"},{"url":"https://escholarship.umassmed.edu/wfc_pp/170","host_type":""}],"fields_of_study":["T-cell and B-cell Immunology","Immune Cell Function and Interaction","Monoclonal and Polyclonal Antibodies Research","Animals","B-Lymphocyte Subsets","Cells, Cultured","Dextrans","Immunoglobulin A","Immunoglobulin Class Switching","Interleukin-4","Interleukin-5","Lipopolysaccharides","Mice","Peritoneum","Spleen","Transforming Growth Factor beta"],"mesh_terms":["Animals","Cells, Cultured","Dextrans","Immunoglobulin A","Lipopolysaccharides","Peritoneum","Spleen","Interleukin-4","Interleukin-5","B-Lymphocyte Subsets","Transforming Growth Factor beta","Immunoglobulin Class Switching","Mice"],"keywords":["Immunoglobulin D","Immunoglobulin class switching","Marginal zone","B cell","Biology","Immunology","B-1 cell","Antibody","In vivo","Follicular phase","Cell biology","Molecular biology","T cell","Immune system","Antigen-presenting cell","Endocrinology","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T11:05:35.848635Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}